Ginkgolide B dropping pill and its preparing method

A technology of ginkgolide and dripping pills, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as inconvenient use, waste of absorption, and high price of ginkgolide B

Inactive Publication Date: 2006-08-09
陈卫东 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Ginkgolide B is insoluble in water and has poor stability. The existing preparations are mainly injections, which are inconvenient to use. The oral preparations show the characteristics of poor absorption in the body after research. Because Ginkgolide B is expensive, the bioavailability is not high, and the absorption is not good. It will cause great waste. In order to improve the efficacy, the present invention proposes an effective solution to improve the bioavailability, which solves the problem of absorption and utilization of the product.

Method used

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  • Ginkgolide B dropping pill and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Ginkgolide B 2g, polyethylene glycol 4000 3.5g, polyethylene glycol 6000 3.5g, mixed, heated to 80°C in a water bath, melted the mixture, stirred evenly, moved into the dripping pill machine, kept at 80°C, the liquid medicine Drop into simethicone oil at 10-15°C, take out the dropping pills, remove simethicone oil, and dry to obtain.

Embodiment 2

[0039] Ginkgolide B 1.5g, polyethylene glycol 6000 5g, sodium stearate 1.5g, glycerin gelatin 1g, mix, heat in a water bath to 80°C, melt the mixture, stir evenly, transfer to the dropping pill machine, keep warm at 78°C , drop the drug solution into the liquid paraffin at 10-15°C, take out the dropping pills, remove the liquid paraffin, and dry to obtain the product.

Embodiment 3

[0041] Ginkgolide B 2.5g, polyethylene glycol 6000 5g, stearic acid 3g, insect wax 1.5g, mix, heat in a water bath to 95°C, melt the mixture, stir evenly, transfer to the dropping pill machine, keep warm at 90°C, Drop the drug solution into the liquid paraffin at 15-22°C, take out the dropping pills, remove the liquid paraffin, and dry to obtain.

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PUM

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Abstract

The present invention relates to a bilobalide B dripping pills preparation and its preparation method. It is formed from effective component bilobalide B and matrix for making dripping pills. The weight ratio of bilobalide B and matrix is 1:1.5-9.

Description

Technical field: [0001] The invention relates to the field of pharmaceutical preparations, in particular to a ginkgolide B drop pill extracted from ginkgo biloba leaves and a preparation method thereof. Background technique: [0002] Ginkgolide (ginkgolide) is one of the main active ingredients of Ginkgo biloba. In 1932, Furukawa isolated terpene lactones from Ginkgo biloba leaves for the first time. In 1967, Maruyama et al. isolated ginkgolides A, B, C and M from the root bark of Ginkgo biloba and determined their chemical structures. In 1987, Weinges isolated ginkgolide J from Ginkgo biloba leaves. Ginkgolide molecule has a unique twelve-carbon skeleton structure, embedded with a tert-butyl group and six five-membered rings, including a spiro[4,4]nonane, a tetrahydrofuran ring and three lactone rings. Ginkgolides A, B, C, M and J are represented by codes BN52020, BN52021, BN52022, BN52023 and BN52024 respectively, wherein the content of BN52021 in Ginkgo biloba is 0.2%....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/20A61P9/10A61P7/02A61P25/28A61P35/00A61P39/06
Inventor 陈卫东刘晓东谢林梁燕
Owner 陈卫东
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