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Ciclesonide oral ulcer paster and its preparing method

A technology of ciclesonide and oral patch, which is applied in the field of anti-oral ulcer drugs and can solve the problems of easy absorption

Inactive Publication Date: 2006-08-09
CHONGQING PHARMA RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug-containing layer is 0.4mm thick, with carbopol and hydroxypropyl methylcellulose as the paste, and the anti-adhesive layer (backing) is 0.7mm thick, which can be pasted in the oral cavity for a long time, but it is easy to absorb and cause systemic hormones class side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Drug-containing layer:

[0029] Ciclesonide 0.1g

[0030] Hydroxypropyl Methyl Cellulose 20g

[0031] Carbopol 5g

[0032] Dextrin 25g

[0033] 12% polyvinylpyrrolidone solution 9-13ml

[0034] Magnesium stearate 0.5g

[0035] Made into 1000 pieces

[0036] Preparation method: Dissolve ciclesonide in 12% polyvinylpyrrolidone ethanol solution. In addition, after hydroxypropyl methylcellulose and carbopol are passed through a 80-mesh sieve, they are mixed with dextrin, and the soft material made of the polyvinylpyrrolidone solution containing the drug ciclesonide is added, stirred evenly, and passed through a 35-mesh sieve. Prepare wet granules, boil and dry the wet granules at about 50°C to obtain dry granules, add magnesium stearate and mix well, and then press into tablets. One side of the pressed tablets is coated with ethyl cellulose, yellow aluminum lake and stearin The ethanol solution of magnesium...

Embodiment 2

[0038] The present invention will be further described below in conjunction with the examples, but not as a limitation of the present invention.

[0039] Drug-containing layer particles:

[0040] Ciclesonide 0.1g

[0041] Hydroxypropyl Methyl Cellulose 20g

[0042] Carbopol 5g

[0043] Dextrin 25g

[0044] 12% polyvinylpyrrolidone solution 9-13ml

[0045] Magnesium stearate 0.5g

[0046]Made into 1000 pieces

[0047] Protective layer particles:

[0048] Ethylcellulose 5g

[0049] Titanium dioxide 15g

[0050] Yellow aluminum lake 1.5mg

[0051] 3% ethyl cellulose ethanol solution appropriate amount

[0052] Magnesium stearate 0.01g

[0053] Made into 1000 pieces

[0054] making process:

[0055] Drug-containing layer granule preparation method: deep ciclesonide in 12% polyvinylpyrrolidone ethanol solution. In addition, after hydroxypropyl methylcellulose and carbopol are passed thro...

Embodiment 3

[0059] Drug-containing layer:

[0060] Ciclesonide 0.6g

[0061] Hydroxypropyl Methyl Cellulose 20g

[0062] Carbopol 5g

[0063] Dextrin 25g

[0064] 12% polyvinylpyrrolidone solution 9-13ml

[0065] Magnesium stearate 0.5g

[0066] Made into 1000 pieces

[0067] Preparation method: Put ciclesonide deep in 12% polyvinylpyrrolidone ethanol solution. In addition, after hydroxypropyl methylcellulose and carbopol are passed through a 80-mesh sieve, they are mixed with dextrin, and the soft material made of the polyvinylpyrrolidone solution containing the drug ciclesonide is added, stirred evenly, and passed through a 35-mesh sieve. Prepare wet granules, boil and dry the wet granules at about 50°C to obtain dry granules, add magnesium stearate, mix well, and then press into tablets, and coat one side of the pressed tablets with ethyl cellulose, magnesium stearate and o-phthalic acid The ethanol solution of dibutyl di...

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PUM

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Abstract

The present invention relates to a sticking tablet for curing stomatocace. Its adhesive layer contains 0.01-2mg of cyclosonide. Said oral sticking tablet can be general single-layer tablet, also can be double-layer tablet including medicine adhesive layer and water-proof protective layer, its adhesive material mainly is selected from hydroxypropyl methyl cellulose, carbopul, carboxymethylcellulose sodium, hydroxypropyl cellulose and polyvinylpyrrolidone.

Description

technical field [0001] The invention relates to an anti-oral ulcer medicine, in particular to an oral patch containing ciclesonide and a preparation method thereof. Background technique [0002] Oral ulcer is exactly commonly called as " aphthous ulcer ", is one of common disease, frequently-occurring disease, and wherein recurrent oral ulcer is the most common, and its sickness rate is more than 20%, and wherein recurrence accounts for 10%. Oral ulcers are localized damage to the oral mucosa characterized by periodic outbreaks, specifically attacking the oral mucosa, usually appearing in the palate, throat, gums, tongue and other parts, severe cases can spread to the pharynx and mucous membranes, some with time, The ulcer area increases, the number increases, the ulcer surface has a severe burning sensation, the pain is unbearable, and it brings inconvenience to life and work. Some have mouth-eye-genital triad (Behcet's disease), which is life-threatening. Therefore, to t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K9/70A61P1/02
Inventor 牟才华代赵明
Owner CHONGQING PHARMA RES INST
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