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Preparation method of aidi injection agent

An injection preparation and preparation technology are applied in the field of preparation of Aidi injection preparations, which can solve the problems of easily causing adverse reactions and poor pharmacological effects.

Inactive Publication Date: 2006-08-30
北京天新园医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The molecular weight range of polysaccharides is very large, and the pharmacological effects of extremely small molecular weight polysaccharides are not good, but injection administration of polysaccharides with large molecular weight can easily cause adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Mylabris 15g, Ginseng 500g, Astragalus 1000g, Acanthopanax 1500g.

[0060] Take the above-mentioned mylabris, crush it, pass through a 60-mesh sieve, put it into an ultrasonic oscillator, add 10 times the amount of 95% ethanol to soak for half an hour, and then extract it by ultrasonic vibration for 40 minutes, frequency 350kHz, and extract 3 times; combine the extracts and let stand , filter, the filtrate is concentrated under reduced pressure into a thick paste, add 10 times the amount of water, stir, stand, filter, the filtrate is centrifuged at a speed of 10000 rpm for 20 minutes, the centrifugate is concentrated under reduced pressure, dried, and dissolved with a small amount of ethanol. Add it to a saturated solution made of 4 times the amount of hydroxypropyl-β-cyclodextrin, stir at 50°C for 3 hours, and then stir for 2 hours at room temperature, let it stand overnight, filter, and dry at low temperature to obtain the inclusion complex of mylabris .

[0061] Tak...

Embodiment 2

[0065] Mylabris 10g, Ginseng 300g, Astragalus 700g, Acanthopanax 1200g.

[0066] Take the above-mentioned mylabris, crush it, pass through a 60-mesh sieve, put it into an ultrasonic oscillator, add 6 times the amount of 80% ethanol to soak for half an hour, and then extract it by ultrasonic vibration for 20 minutes and a frequency of 30kHz. Extract twice; combine the extracts and let stand , filter, the filtrate is concentrated under reduced pressure into a thick paste, add 8 times the amount of water, stir, stand, filter, the filtrate is centrifuged at a speed of 15000 rpm for 10 minutes, the centrifugate is concentrated under reduced pressure, dried, dissolved with a small amount of ethanol, Add it to a saturated solution made of 6 times the amount of hydroxypropyl-β-cyclodextrin, stir at 50°C for 3 hours, and then stir for 2 hours at room temperature, let it stand overnight, filter, and dry at low temperature to obtain the inclusion complex of mylabris .

[0067] Take the ...

Embodiment 3

[0071] Mylabris 12g, Ginseng 400g, Astragalus 850g, Acanthopanax 1300g.

[0072]Take the above-mentioned mylabris, crush it, pass through a 60-mesh sieve, put it into an ultrasonic oscillator, add 8 times the amount of 90% ethanol to soak for half an hour, and then extract it by ultrasonic vibration for 30 minutes, frequency 40kHz, and extract twice; combine the extracts and let stand , filter, the filtrate is concentrated under reduced pressure into a thick paste, add 10 times the amount of water, stir, stand, filter, the filtrate is centrifuged at a speed of 12000 rpm for 15 minutes, the centrifugate is concentrated under reduced pressure, dried, and dissolved with a small amount of ethanol. Add it to a saturated solution made of 5 times the amount of hydroxypropyl-β-cyclodextrin, stir at 50°C for 3 hours, and then stir for 2 hours at room temperature, leave it overnight, filter, and dry at low temperature to obtain the inclusion complex of mylabris .

[0073] Take the abov...

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PUM

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Abstract

A process for preparing Aidi injection is disclosed. Said Aidi injection features high curative effect, low poison and less untoward effect.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a preparation method of Aidi injection preparation. technical background [0002] Aidi Injection (Ministry of Traditional Chinese Medicine 20 volumes) is a compound pure Chinese medicine preparation made from 4 traditional Chinese medicines of Mylabris, Ginseng, Astragalus, and Acanthopanax. Hepatocellular carcinoma, lung cancer, rectal cancer, malignant lymphoma, treatment of gynecological malignant tumors, etc. Cantharidin in the prescription is the king drug, which has the function of "breaking blood and eliminating symptoms, attacking poisonous ulcers". The main active ingredient cantharidin has the effect of cytotoxicity and induction of cell apoptosis, which can strengthen the cytotoxicity of chemotherapy drugs and can Induce cell apoptosis. Experiments show that it can inhibit the growth of tumor cells, and its inhibitory effect is achieved by interfering wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/08A61K9/14A61K9/19A61P35/00A61K35/64
Inventor 魏海关
Owner 北京天新园医药科技开发有限公司
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