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Optical glucose sensor chip

A sensor chip, glucose technology, applied in biochemical equipment and methods, analysis by chemical reaction of materials, material analysis by observing the impact on chemical indicators, etc. The effect of inhibiting dissolution and good diffusion

Inactive Publication Date: 2006-09-06
KK TOSHIBA
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, if the above-mentioned extraction medium is heated, since the dissolution of the sensing membrane is promoted, the chromogenic agent or enzyme is eluted from the sensing membrane, and there is a problem that the sensitivity of the chip decreases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0019] figure 1 It is a cross-sectional view showing the optical glucose sensor chip according to the first embodiment.

[0020] The glass substrate 1 has, for example, 3 nm or more on the main surface. Thickness of SiO 2 Surface 2. The optical components are made in the above SiO 2 The surfaces near the two edges of the surface layer 2 are respectively formed by injecting light into the substrate 1 or emitting light in the substrate 1, and a pair of gratings 3 are used. In addition, the optical components can also be replaced with prisms. These gratings 3 are made of SiO 2 The refractive index of the surface layer 2 is composed of, for example, titanium oxide. A protective film having a lower refractive index than the above-mentioned grating 3 is formed to cover the above-mentioned grating 3. The material of the protective film is made of, for example, a fluorine-based resin that does not react with the chemicals or samples used.

[0021] The SiO of the substrate 1 located betw...

Embodiment approach 2

[0037] figure 2 It is a cross-sectional view showing the optical glucose sensor chip according to the second embodiment.

[0038] In order to inject and emit light on the glass substrate 11, a pair of gratings 12 as optical components are respectively formed near both edges of the main surface of the glass substrate 11. These gratings 12 are made of, for example, titanium oxide having a higher refractive index than the above-mentioned substrate 11. A light reflection path layer 13 made of a thermosetting or photocurable resin having a higher refractive index than the substrate 11 is formed on the main surface of the substrate 11 including the grating 12. The light reflection path layer 13 is formed so that its main surface is parallel to the main surface of the substrate 11 including the grating 12. A glucose sensor film 14 is formed on the light reflection path layer 13 corresponding to the part between the gratings 12. The glucose sensor film 14 contains an enzyme that oxidize...

Embodiment 1

[0056] Mix 1436μL of isopropanol (IPA), 956μL of pure water, 210μL of 0.01 mol / L, pH 6.0 phosphate buffer, 60μL of 1% by volume polyethylene glycol (PEG) in isopropanol solution, 600μL of 1mg / ml of 3,3',5,5'-tetramethylbenzidine (TMBZ) in isopropanol, 640μL of 2% by weight carboxymethylcellulose (CMC) aqueous solution, 8μL of 1% by weight Linked polymer compound (2-methacryloyloxyethyl phosphorylcholine and butyl methacrylate copolymer) aqueous solution, 0.67 mg / mL peroxidase (POD) solution (dissolved in 0.01 mol / L Phosphate buffer (pH: 6.0)) and 5.33 mg / mL glucose oxidase (GOD) solution (dissolved in 0.01 mol / L phosphate buffer (pH: 6.0)), stir to prepare 4000 μL for generating glucose sensor Film coating liquid.

[0057] Next, prepare SiO with a thickness of 10nm on the main surface 2 The surface layer of the alkali-free glass substrate with a refractive index of 1.52, by sputtering, the SiO on the substrate 2 A titanium oxide film with a refractive index of 2.2 to 2.4 and a th...

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Abstract

An optical glucose sensor chip comprises a glass substrate, a first optical element formed on a major face of the substrate for impinging light into the substrate, a second optical element formed on the major face of the substrate for emitting the light to the outside, and a glucose sensing membrane formed on the major face of the substrate situated between the first and second gratings. The glucose sensing membrane comprises a color developer, a first enzyme for oxidizing or reducing glucose, a second enzyme for generating a substance for developing the color developer by reacting with a product of the first enzyme, a film-forming polymer compound, and a cross-linking polymer compound.

Description

Technical field [0001] The invention relates to an optical glucose sensor chip. Background technique [0002] As an optical glucose sensor chip, for example, a low-invasive blood glucose measurement chip has been developed that detects blood glucose levels indirectly by extracting body fluids from subcutaneous tissues. The sensor chip has a structure with the following components: a glass substrate, and a pair of gratings formed on the surface of the substrate for incident and radiating light in the substrate, and a pair of gratings formed on the surface of the substrate between the gratings Glucose sensing membrane. The glucose sensing membrane contains a color developer (for example, 3,3',5,5'-tetramethylbenzidine (TMBZ)), an enzyme that oxidizes or reduces glucose (for example, glucose oxidase (GOD)), and the The product formed by the first enzyme reacts to produce a second enzyme (for example, peroxidase (POD)) and film-forming polymer compounds (for example, cellulose such a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78G01N33/66C12Q1/00
Inventor 植松育生东野一郎大宫可容子
Owner KK TOSHIBA
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