Method for extracting 'Danfen' phenolic acid-A

An extraction method and technology of salvianolic acid, which is applied in the field of extraction of pharmaceutical ingredients, can solve the problems of difficulty in large-scale production and low extraction rate of salvianolic acid A, and achieve the effects of low production cost, good purity and stable performance

Inactive Publication Date: 2006-09-13
PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the content of salvianolic acid A in medicinal materials is very low, sometimes even no, the extraction rate of salvianolic acid A is very low, which causes difficulties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment one A kind of extraction method of salvianolic acid A:

[0021] Take 250 kg of Salvia miltiorrhiza granules, add 6 times the amount of 60% ethanol for ultrasonic extraction 3 times, each time for 20 minutes, and the ultrasonic extraction temperature is 30°C. The extracts were combined, centrifuged with three legs, the centrifugate was concentrated under reduced pressure, the temperature was controlled at 60°C, and concentrated to 1:1, and the concentrated solution was placed in a reaction kettle at 120°C for 8 hours. Take the above-mentioned medicinal solution and pass it through the macroporous resin column, the ratio of the sample amount (calculated based on the dry weight of the original medicinal material) to the macroporous resin is 1:5, first wash with 10 times the column volume of water to remove impurities, and then wash with 10 times the column volume concentration Rinse with 20% ethanol water to remove impurities, then rinse with 40% ethanol water s...

Embodiment 2

[0022] Example 2 An extraction method of salvianolic acid A: basically the same as Example 1, the difference is ultrasonic extraction with water. details as follows:

[0023] Salvia miltiorrhiza granules, add 6 times the amount of water, ultrasonic extraction 3 times, 40 minutes each time, ultrasonic temperature 40 ℃.

Embodiment 3

[0024] Example 3 An extraction method of salvianolic acid A: basically the same as Example 2, the difference is that the ultrasonic temperature is 0°C, specifically as follows:

[0025] Salvia miltiorrhiza granules, add 6 times the amount of water, ultrasonic extraction 3 times, 90 minutes each time, ultrasonic temperature 0 ℃.

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PUM

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Abstract

A process for preparing danshinolic acid A from red sage root includes such steps as extracting in water or alcohol, concentrating, high-temp and -pressure reaction, purifying by chromatographic column, regulating pH value, extracting in organic solvent, concentrating and drying.

Description

technical field [0001] The invention relates to a method for extracting medicinal components, in particular to a method for extracting salvianolic acid A from salvia miltiorrhiza. Background technique [0002] Salvia miltiorrhiza is one of the most commonly used medicinal materials for promoting blood circulation and is used to treat cardiovascular and cerebrovascular diseases such as angina pectoris, hypertension, coronary heart disease and stroke. In the past two decades, the research on salvianolic acid compounds, the main active components of Danshen, has been active. In vitro and in vivo experiments have shown that salvianolic acid compounds can also treat various diseases, such as tumors, liver diseases, kidney diseases, and peptic ulcers, in addition to treating cardiovascular and cerebrovascular diseases. Most researchers focus on total phenolic acids or salvianolic acid B, while ignoring salvianolic acid A with lower content and stronger activity. [0003] After 2...

Claims

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Application Information

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IPC IPC(8): C07C67/48C07C69/73
Inventor 朱长福王国振
Owner PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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