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Compounding suspension contg. niclosamidum for killing oncomelania, and its prepn. method

The technology of niclosamide and suspending agent is applied in the field of snail-killing drug niclosamide compound suspending agent and preparation thereof, and can solve the problems of high price of niclosamide, insoluble in water, inconvenient on-site application, and the like, Achieve the effect of improving snail killing effect, reducing cost and reducing dosage

Inactive Publication Date: 2006-11-29
JIANGSU INST OF PARASITIC DISEASES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The price of niclosamide is relatively expensive, how to reduce the dosage and cost has always been a major problem that urgently needs to be solved in the work of schistosomiasis control and molluscicide
We have screened out a drug that has a high synergistic molluscicidal effect on niclosamide - chlorophom (B002), but chlorophom is also difficult to dissolve in water and cannot be conveniently used for on-site application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: the preparation of niclosamide compound suspension

[0010] In mass percent, 25% niclosamide, 25% phoxim, 2.0% alkyl glycosides, 4% glycerol, 0.1% sodium carboxymethylcellulose, 0.2% sodium benzoate, 1.0% methyl Silicone oil and the rest are water. After the ingredients are mixed according to the formula, they are added to a ball mill tank at a speed of 400r / min, and the ball mill is used to grind for 4 hours to obtain the niclosamide compound suspending agent.

Embodiment 2

[0011] Embodiment 2: the preparation of niclosamide compound suspension

[0012] In terms of mass percentage, 20% niclosamide, 20% chlorophom, 1.0% sodium methylnaphthalenesulfonate, 2% Tween-80, 0.1% gum arabic, 0.2% sodium benzoate, 1.0% methyl Silicone oil and the rest are water. After the ingredients are mixed according to the formula, they are added to a ball mill tank at a speed of 300 r / min, and the ball mill is used to grind for 4 hours to obtain the niclosamide compound suspending agent.

Embodiment 3

[0013] Embodiment 3: the preparation of niclosamide compound suspension

[0014] In terms of mass percentage, 5% niclosamide, 5% chlorphoxim, 0.5% sodium dodecyl sulfonate, 1% dimethyl octane glycol, 1% sodium carboxymethylcellulose, 0.2% Sodium benzoate, 1.0% methyl silicone oil, and the rest are water. After the ingredients are mixed according to the formula, they are added to a ball mill tank at a speed of 200r / min, and the ball mill is used to grind for 2 hours to obtain the niclosamide compound suspending agent.

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PUM

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Abstract

A composite insecticide in the form suspension for killing oncomelania is prepared from teniarene, chlorphoxim, wetting agent, disperser, viscosity regulator, antiseptic, defoaming agent, and water through proportional mixing, and ball grinding.

Description

technical field [0001] A snail killing drug niclosamide compound suspension and a preparation method thereof, which belong to the oncomelania drug preparation [0002] technology field. Background technique [0003] Niclosamide is insoluble in water and organic solvents. In order to solve the dispersion and use of niclosamide, we make it into a suspension concentrate, which has good dispersibility, suspension and molluscicidal effect. The price of niclosamide is relatively expensive, how to reduce the dosage and cost has always been a major problem that needs to be solved urgently in the work of schistosomiasis control and molluscicide. We have screened out a drug that has a higher synergistic molluscicidal effect on niclosamide - chlorphom (B002), but chlorphom is also insoluble in water and cannot be conveniently applied on site. Therefore, on the basis of research on synergists and suspending agents, an attempt was made to combine niclosamide and synergist chlorphoxim t...

Claims

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Application Information

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IPC IPC(8): A01N57/14A01P9/00A01N37/48
Inventor 戴建荣朱荫昌梁幼生王浦海
Owner JIANGSU INST OF PARASITIC DISEASES
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