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Biosensor of full fiber optic evanescent wave

A biosensor and all-fiber technology, applied in the coupling of optical waveguide, fluorescence/phosphorescence, material excitation analysis, etc., can solve problems that do not involve technical solutions, reduce energy loss, improve coupling efficiency, and simplify instrument structure. Effect

Inactive Publication Date: 2006-12-06
TSINGHUA UNIV
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  • Summary
  • Abstract
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Problems solved by technology

[0004] After searching, there is no technical solution related to the relevant content of the present invention in the currently published literature

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  • Biosensor of full fiber optic evanescent wave
  • Biosensor of full fiber optic evanescent wave
  • Biosensor of full fiber optic evanescent wave

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Experimental program
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Embodiment Construction

[0012] see figure 1 , figure 1 It is a structural schematic diagram of the all-fiber evanescent wave biosensor of the present invention. It can be seen from the figure that the all-fiber evanescent wave biosensor of the present invention includes a laser emitting device, a laser transmission and fluorescence receiving optical path, a sample flow path, a fluorescence collection device and a data processing device. The laser emitting device includes a pulse laser 1 and a pulse signal generator 10; the laser transmission and fluorescence receiving optical path includes a laser-to-fiber coupler 2, a single-mode and multi-mode fiber coupler 5, and an optical fiber probe 8; the sample flow path includes a sample pool 9, The peristaltic pump 13 has a sample cell inlet 7 and a sample cell outlet 14 on the sample cell; the fluorescence acquisition and data processing device contains a fluorescence filter 4, a photodetector 3, a lock-in amplifier 11 and a computer 12.

[0013] Depend ...

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Abstract

The invention relates to a full optical fiber instant passing wave biology sensor technology to realize biological detection by using laser to excite the biology material to emitting. The feature is that the laser transferring and fluorescence receiving path of the sensor contains an optical fiber probe, a single and multiple optical fiber coupler. The laser from the laser emitting device would send to the end of the single-mode optical fiber, and the other end coupling to multimode fiber. One end of the multimode fiber connects to fiber probe, and the other end locating in the light incidence end of fluorescence collecting and data processing device. The invention could decrease the consumption, improve coupling efficiency and decrease optical discrete element and simplify instrument structure.

Description

Technical field: [0001] The all-fiber evanescent wave biosensor belongs to the technical field of biological detection, and in particular relates to the technology of using laser to excite biological substances marked with fluorescent molecules to emit light, so as to realize biological detection. Background technique: [0002] Optical fiber evanescent wave biosensors use light waves to generate evanescent waves in the medium where the optical fiber probe is located when light waves are transmitted in the form of total reflection in the optical fiber. Biological substances labeled with fluorescent molecules on the surface, so as to achieve the purpose of detecting the concentration of the target substance to be tested. Usually the penetration depth of the evanescent wave field is only tens of nanometers to hundreds of nanometers, so the optical fiber evanescent wave biosensor can only detect the fluorescence emitted by the fluorescent molecules combined in the evanescent wav...

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Application Information

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IPC IPC(8): G02B6/26G02B6/42G01N21/64
Inventor 施汉昌龙峰何苗
Owner TSINGHUA UNIV
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