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Preparation method and application of water-soluble mangiferin monosodium salt

A technology of monosodium glycoside and mangiferin, which is applied in the field of chemical pharmacy, can solve the problems of poor water solubility, difficult medicinal liquid, influence on curative effect and its application, etc.

Inactive Publication Date: 2007-02-28
广西中医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, mangiferin is a tetrahydroxyl ketone carbon glycoside, which has very poor water solubility, and it is difficult to make a stable medicinal solution with a suitable concentration, which affects its curative effect and application.

Method used

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  • Preparation method and application of water-soluble mangiferin monosodium salt
  • Preparation method and application of water-soluble mangiferin monosodium salt
  • Preparation method and application of water-soluble mangiferin monosodium salt

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Place the 50ml three-necked bottle equipped with a stirrer and dropping funnel in a constant temperature water bath that has been heated to 60°C, add 5ml acetone and 2ml water in the three-necked bottle, add 0.422g mangiferin (0.001mol), and stir After the mangiferin and the solvent are fully mixed, 1.5% sodium bicarbonate solution (5.6ml, 0.001mol) is added dropwise while stirring, and the dripping is completed within 15 minutes. Continue to stir, and react at a constant temperature for 5 to 10 minutes, and the solution becomes clear. Quickly add 30ml of acetone, stir for 5-10min, cool to room temperature, filter, wash with acetone, and dry in a vacuum oven at 50-60°C for 2-3h to obtain 0.412g of mangiferin monosodium salt with a weight yield of 92.8%. The product obtained was yellow powder in appearance.

Embodiment 2

[0010] Place the 50ml three-necked bottle equipped with a stirrer and dropping funnel in a constant temperature water bath that has been heated to 60°C, add 8ml acetone and 1ml water in the three-necked bottle, add 0.422g mangiferin (0.001mol), and stir After the mangiferin and the solvent are fully mixed, 1.5% sodium bicarbonate solution (5.6ml, 0.001mol) is added dropwise while stirring, and the dripping is completed within 15 minutes. Continue to stir, and react at a constant temperature for 5 to 10 minutes, and the solution becomes clear. Quickly add 20ml of dichloromethane and acetone (volume ratio 1:1) mixed solution, stir for 10-15min, filter, wash with acetone, and dry in a vacuum oven at 50-60°C for 4-5h to obtain 0.364g of monosodium mangiferin, weight The yield was 81.9%. The product obtained was yellow powder in appearance.

Embodiment 3

[0012] Place the 50ml three-necked bottle equipped with a stirrer and dropping funnel in a constant temperature water bath that has been heated to 60°C, add 3ml acetone and 2ml water in the three-necked bottle, add 0.422g mangiferin (0.001mol), and stir After the mangiferin and the solvent are fully mixed, 1.5% sodium bicarbonate solution (5.6ml, 0.001mol) is added dropwise while stirring, and the dripping is completed within 15 minutes. Continue to stir, and react at a constant temperature for 5 to 10 minutes, and the solution becomes clear. Quickly add 40ml of dichloromethane and acetone (volume ratio 1:1) mixed solution, stir for 10-15min, filter, wash with acetone, and dry in a vacuum oven at 50-60°C for 4-5h to obtain 0.375g of monosodium mangiferin, weight The yield was 84.5%. The product obtained was yellow powder in appearance.

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Abstract

The invention discloses a chimonin reserving method, which is characterized by the following: maintaining main frame; utilizing NaHCO3 to decorate structure of 3-position phenolic hydroxyl group with strong acid; generating single sodium salt of chimonin with structure formula as formula I.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy, and in particular relates to a preparation method of the compound mangiferin monosodium salt and its pharmacological effects of antitussive, phlegm-resolving and anti-inflammation. Background technique: [0002] Mangiferin, also known as mangiferin, zhimuning. It widely exists in Liliaceae Anemarrhena, Anacardaceae mango tree, almond tree leaves, fruits and bark, Gentianaceae Northeast Gentiana, Western Sichuan Swert, Water Keelaceae Guangshiwei and other plants. Mangiferin is the main component of mango leaves. Mango leaves have the advantages of wide distribution, rich medicinal resources, easy to obtain raw materials, low prices, and even four seasons. The content of its main component, mangiferin, reaches 1.92%. Mangiferin has various physiological activities and pharmacological effects. Mangiferin can relieve cough, eliminate phlegm, relieve asthma, anti-inflammation, immunity, protect liv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04A61K31/7048A61P29/00A61P11/14
Inventor 邓家刚袁叶飞
Owner 广西中医学院
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