Use of chloride 13-hexyl berberine in preparation of medicine for treating peptic ulcer and bacteriological gastroenteritis
A technology of peptic ulcer and berberine, applied in the direction of antibacterial drugs, digestive system, drug combination, etc., can solve the problem of no experimental research report and so on
Inactive Publication Date: 2007-03-07
CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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- Abstract
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Problems solved by technology
Its mechanism of action may be related to anti-Hp, anti-inflammation, and participation in the regulation of inflammatory cytokines, but there is no experimental research report
Method used
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Experimental program
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Embodiment 1
[0019] The preparation of embodiment tablet
[0020] Weighing: HB-13 0.005g,
[0021] Microcrystalline cellulose (100 mesh) 0.025g
[0022] Starch (120 mesh) 0.008g
[0023] LU magnesium powder (100 mesh) 0.015g
[0025] Magnesium stearate 0.004g
[0026] Mix the auxiliary materials, dry at 100°C for later use, then mix in the main ingredient HB-13, and press into tablets.
Embodiment 2
[0027] The preparation of embodiment two capsules
[0028] Weighing: HB-13 0.005g
[0029] Starch 0.20g
[0030] Lactose 0.05g
[0031] Fill the No. 4 capsule after mixing.
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The invention relates to a method for using alcaine 13-hexyl berberine to prepare the drug that treats gastritis enteritis caused by pylorus bacillus (Hp), etc. Wherein, alcaine 13-hexyl berberine is the derivate replaced by replacing the thirteenth -H with hexyl -C6H13 in parent compound alcaine berberine, its MIC resistant to pylorus bacillus is 2 mug / ml, and anti-inflammatory cell factor is IC505-10 mug / ml. It has stronger activity then alcaine berberine. And it can be made into oral tablet and capsule.
Description
technical field [0001] The invention relates to the drug application of the compound 13-hexylberberine hydrochloride (hereinafter referred to as HB-13) to treat gastritis and peptic ulcer related to Helicobacter pylori (Hp) and gastroenteritis caused by various bacteria. Background technique [0002] According to modern etiology, Hp infection is the main cause of chronic gastritis and peptic ulcer. The human gastric mucosa is the natural colonization site of Hp, which mainly adheres to the mucus layer. Therefore, the use of anti-Hp drugs is an important and key measure in the treatment of gastritis, gastric and duodenal peptic ulcer. [0003] In addition to anti-Hp infection drugs, the current main drugs for the treatment of gastritis and peptic ulcer include antacid and antacid secretion drugs, gastric mucosal protective drugs, and gastric motility promoting drugs. Among them, most anti-Hp drugs have a high clearance rate of Hp, but a low eradication rate. The combination...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K31/4375A61K9/20A61K9/48A61P1/12A61P31/04
Inventor 郑家润张崇璞李耐三李新宇唐美育高纪伟徐兰芳
Owner CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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