Fasudil-containing preparation and method of improving stability thereof
A technology of fasudil and photostability, applied in medical preparations containing active ingredients, organic active ingredients, organic chemistry, etc., can solve problems such as difficulty in confirming the state of the internal liquid medicine, and achieve excellent visibility, Effect of cost control and stability improvement
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment
[0058] [reference manufacture example]
[0059] Add homopiperazine (3.413g) to tetrahydrofuran (57ml), stir and dissolve, then cool to -5°C, and add 5-isoquinolinesulfonyl chloride hydrochloride while keeping the internal temperature at or below 10°C Salt (3.00g), stirred at 5°C for 4 hours. Next, the reaction mixture was returned to room temperature, the insoluble matter was filtered off, and the filtrate was concentrated under reduced pressure, then ethyl acetate (57 ml), water (17 ml), and 3 standard hydrochloric acid (6.4 ml) were added for separation to obtain an aqueous layer. After washing the obtained aqueous layer with ethyl acetate (7 ml), water (6 ml), ethyl acetate (57 ml), and 6 standard aqueous sodium hydroxide solution (3 ml) were added to the aqueous layer, and the layers were separated to obtain an organic layer. After concentrating the organic layer under reduced pressure, fasudil (1.36 g) was obtained by drying under reduced pressure. The yield in this cas...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More