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Antibacterial and antiviral medicinal composition and its preparation

A composition and anti-virus technology, which is applied in the field of medicine, can solve problems that have not been reported, and achieve the effects of high drug purity, reduced drug dosage, and definite clinical curative effect

Inactive Publication Date: 2012-02-22
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Modern pharmacology and pharmacodynamic studies have shown that 14-dehydroxy-11,12-didehydroandrographolide-3,19-disuccinic acid half ester salt and forsythia have antibacterial, antiviral, anti-inflammatory and analgesic effects. Very good curative effect. At present, Yanhuning and Chuanhuning injections with single active ingredients have been listed on the market, and Forsythia mostly works in a compatible way. - The interaction between didehydroandrographolide-3,19-disuccinic acid half ester salt and forsythia, the compatibility formula has not been reported yet

Method used

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  • Antibacterial and antiviral medicinal composition and its preparation
  • Antibacterial and antiviral medicinal composition and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0131] Example 1 Preparation of Forsythia Extract

[0132] 1. Preparation of Forsythia take Forsythia medicinal material, crush it into coarse powder, add water to decoct 3 times, add 10 times the amount of water for the first time, 8 times the amount for the second and third times, each time for 1.5 hours, combine the decoction, filter After filtration, the filtrate (50°C) was concentrated under reduced pressure to a clear paste with a relative density of 1.10-1.20 (room temperature), let it cool, added 4 times the amount of ethanol, stirred well, stood for 2 hours, filtered, and the filtrate was decompressed to recover ethanol , the concentrated solution is spray-dried to obtain the extract of Forsythia ie crude extract (for oral use).

[0133] 2. Refining of forsythia extract Take forsythia extract, add appropriate amount of water, heat to dissolve, add the solution to the pre-treated and packed D 2820 type macroporous adsorption resin (the ratio of extract and resin is 1:...

Embodiment 2

[0147] Embodiment 2 Preparation of the composition powder injection of the present invention

[0148] prescription:

[0149] Yanhuning 40g

[0150] Forsythia extract 333g (equivalent to 30kg forsythia)

[0151] Mannitol 300g

[0152] Add sterile water for injection to 3000ml

[0153] A total of 1000 sticks were prepared

[0154] Preparation Process:

[0155] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0156] 2) Weigh the raw materials and auxiliary materials according to the prescription quantity.

[0157] 3) Take water for injection with a dosing volume of 40%, add the prescribed amount of Yanhuning, heat and stir to dissolve completely. Forsythia extract add a small amount of water for injection, heat to dissolve. Combine the above solutions, then add mannitol, heat and stir to dissolve completely, and add sterile water for injection to the full amoun...

Embodiment 3

[0165] Example 3 Preparation of the composition aqueous injection of the present invention

[0166] prescription:

[0167] Yanhuning 40g

[0168] Forsythia extract 333g (equivalent to 30kg forsythia)

[0169] Add water for injection to 2000ml

[0170] A total of 1000 sticks were prepared

[0171] Preparation Process:

[0172] 1) Dispose of the pipes and containers used for liquid preparation in one day, and rinse them with fresh water for injection before use.

[0173] 2) Take 40% of the water for injection, add the prescribed amount of Yanhuning to dissolve completely, add a small amount of water for injection to the forsythia extract, and heat to dissolve.

[0174] 2) Combine the above solutions and add water for injection to the full amount.

[0175] 3) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.

[0176] 4) Decarburization by sand filter rod filtration. Measure and adjust the pH of the solution.

[0177] 5) Fine fil...

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Abstract

A Chinese medicine in the form of injection or any orally taken form for preventing and treating inflammation, cough, emesis, hyperlipemia, etc, improving immunity, protecting liver, etc is proportionally prepared from 14-dehydroxy-11,12-didehydro andrographolide-3,19-semiester succinate or its pharmacologically acceptable salt and forsythia fruit or its extract. Its preparing process is also disclosed.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and relates to a compound composed of 14-dehydroxyl-11,12-didehydroandrographolide-3,19-disuccinic acid half ester or a pharmaceutically acceptable salt thereof and forsythia or forsythia The pharmaceutical composition made from the extract and its preparation method and application. 【Background technique】 [0002] Due to the current spread of resistance to many traditional antibiotics such as penicillin and amoxicillin has attracted great attention and attention from the medical community, a large number of multi-drug resistant strains and the emergence of new viruses have made refractory infections more and more serious. many. At the same time, since the compatibility of natural medicines such as traditional Chinese herbal medicines or the composition of active ingredients often have complementary and synergistic effects, and do not produce drug resistance, the discovery and research of nat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/634A61K31/365A61P31/04A61P31/12A61P29/00
Inventor 蔡军
Owner 海安江理工技术转移中心有限公司