Application of Pancreatic Kallikrein in Preparation of Drugs for Radiation Therapy of Tumors
A technique of pancreatic kininogenase and radiotherapy, which is applied to the application field of medicine, can solve the problems of increasing toxic and side effects, aggravating toxic and side reactions, etc., and achieves the effects of improving transmission, reducing oxygen partial pressure, and improving curative effect.
Active Publication Date: 2012-02-22
CHANGZHOU QIANHONG BIOPHARMA
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Problems solved by technology
If you have tried the hyperbaric oxygen chamber method, the oxygen carrier (artificial blood) method and the use of vasodilators (pentoxifylline, etc.) have not achieved satisfactory results
The reason is that although these methods can increase the oxygen level of the tumor, they also significantly increase the partial pressure of oxygen in normal tissues at the same time, and the obvious increase in the partial pressure of oxygen in normal tissues is the main reason for the aggravation of the toxic and side effects of radiation.
Therefore, the toxic and side effects of normal tissues to radiation are increased, making these methods unacceptable. People are looking forward to a method that not only sensitizes but also attenuates the toxicity.
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[0018] Preparation of pancreatic kininogenase injection.
[0019] Take 779,000 units of filtered sterilized pancreatic kininogenase raw material drug, add 5 grams of mannitol, add 10 grams of lactose, add appropriate amount of water for injection to dissolve, then add water for injection to 500 ml, filter aseptically, and pack into 1000 pencillins bottle, freeze-dried, ready to use.
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The invention discloses a new application of pancreatic kininogenase, that is, the application in the preparation of drugs for radiotherapy of tumors, mainly used to reduce transmission block, improve the transmission of oxygen to tumor tissue; increase the oxygen content of tumor tissue It has the sensitizing and attenuating effects of radiation therapy. After the use of pancreatic kininogenase, inhalation of gas with different concentrations of oxygen content is used to increase the oxygen partial pressure of tumor tissue and improve the curative effect of radiation therapy on tumors. Moreover, it can also avoid the aggravation of the toxic and side effects of radiation after inhalation of high oxygen gas and hypoxic gas by normal tissues.
Description
technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to the application of pancreatic kininogenase in the preparation of medicaments for radiotherapy of tumors. Background technique [0002] Pancreatic Kininogenase, also known as vasodilation, is extracted and purified from mammalian pancreas. It acts on kininogen to release kinin. In the form of local hormones, kinin binds to the kinin B2 receptor present on the vascular endothelium to activate phospholipase, which hydrolyzes membrane phospholipids into arachidonic acid and inositol triphosphate. Then activate the prostaglandin synthesis system and nitric oxide synthesis system, increase the levels of prostacyclin and nitric oxide in the blood, relax blood vessels and inhibit the proliferation of damaged vascular intima. Pancreatic kininogenase itself belongs to the serine protease class, it can catalyze plasminogen to generate plasmin, and the kinin released by it ca...
Claims
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IPC IPC(8): A61P35/00A61K38/08
Inventor 王耀方张叔伦阮桂
Owner CHANGZHOU QIANHONG BIOPHARMA