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Vegetative hard capsule casing material and its prodn. method

A hard capsule shell, plant-based technology, applied in the field of materials, can solve problems such as the spread of mad cow disease

Inactive Publication Date: 2007-04-18
上海慧源植物胶囊股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although gelatin has good properties in the preparation of hard capsules, gelatin as a heterologous protein may be antigenic
For example, imported bovine-derived gelatin materials may contain prions, and soft capsules made from them may cause the spread of mad cow disease

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0054] The preparation method of the vegetable hard capsule shell of the present invention can be carried out on the existing equipment for preparing gelatin hard capsule shell. Under the condition that no additional equipment is required, the required vegetable hard capsule shell can be prepared by adjusting parameters such as drying temperature, humidity, coating film thickness, and operating speed according to the formula.

[0055] Compared with the prior art, the main advantages of the present invention are:

[0056] (1) The colloidal material used to prepare the capsule shell is mainly hydrophilic plant colloid, and does not contain animal protein and fat, thereby avoiding possible pollution caused by animal protein.

[0057] (2) Optionally add plasticizers listed in the present invention.

[0058] (3) The hydrophilic plant gel is easy to dissolve, which can save the necessary water absorption and swelling stage when making gelatin capsules, and save production time.

...

Embodiment 1

[0063] Raw material formula

[0064] The production method is as follows: weigh 1 gram of κ-type carrageenan and 2 grams of glycerin, pour it into 72 grams of deionized water, heat to 90°C, dissolve evenly, then pour hypromellose into it, stir evenly, and pour the material into The temperature of the solution was lowered to 55°C, and the capsule shell was prepared by dipping in glue. Dry at about 35° C., control the water content of the capsule film within 3%-10%, and obtain 27.5 grams of plant-based hard capsule shells in total. The finally obtained vegetable hard capsule shell is transparent and has good elasticity.

Embodiment 2

[0066] formula

[0067] The production method is as follows: weigh 0.5 grams of κ-type carrageenan, 9.5 grams of povidone, and 2 grams of polyethylene glycol into 70 grams of deionized water, heat to 90 ° C, dissolve evenly, and then pour hypromellose into Stir well, and after heat preservation and bubble elimination, the capsules are prepared by dipping in glue. Dry at about 30°C, control the water content of the capsule film within 3%-10%, and obtain 32 grams of plant-based hard capsule shells in total. The finally obtained plant-based hard capsule shell is transparent, elastic and has a good taste.

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Abstract

A vegetative shell of capsule is prepared from hydrophilic vegetative gel, adhesive, plasticizer and water. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of materials, in particular to components and production methods of hard capsule shells. Background technique [0002] At present, the film of hard capsules is made from gelatin extracted from animal bones or skins such as cattle and pigs. Although gelatin has excellent properties in the preparation of hard capsules, gelatin, as a heterologous protein, may be antigenic. For example, imported bovine-derived gelatin materials may contain prions, and soft capsules made from them may cause the spread of mad cow disease. With the increasing market demand for plant-derived materials, it is imminent to develop plant-based hard capsule materials other than gelatin. [0003] In order to avoid the infection of human diseases that may be caused by animal proteins, there is an urgent need in this field to develop new non-gelatin, plant-based hard capsule shell materials and their production processes. Contents of the inventio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48
Inventor 张士楚吴国庆
Owner 上海慧源植物胶囊股份有限公司
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