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Application of Entamoeba histolytica for treating malignant noumenal tumor

A technology for amoebas and solid tumors, which is applied in the application field of histolytic amoebas in the treatment of malignant solid tumors, and can solve the problems of decreased patient resistance, poor curative effect, and high treatment costs for patients

Inactive Publication Date: 2007-04-18
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical treatment of tumors mostly adopts comprehensive treatment based on surgery, including chemotherapy, physical therapy (radiation, ultrasound, hyperthermia, low temperature technology, etc.), biological therapy, and traditional Chinese medicine treatment, but none of them are ideal.
Surgical treatment of cancer patients causes great damage and is easy to transfer. Radiotherapy and chemotherapy can easily kill the patient's normal tissue and destroy the patient's immune system, reducing the patient's resistance. Moreover, the patient's treatment costs are high, the curative effect is poor, and the side effects are large.
There is no report on the application of histolytic amoeba in the treatment of malignant solid tumors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Establishment of human liver cancer metastasis model LCI-D20 (LCI-D35) in nude mice and amoeba biological excision treatment

[0017] (1) Culture of pathogenic histolytic amoeba

[0018] Mainly use Robinson’s medium, which can not only cultivate histolytic amoeba, but also cultivate various amoebas such as Harmen’s Entamoebae, Colonic Entamoebae, and micro-Entamoebae. General application 6-7ml or smaller spiral cap culture tube.

[0019] 1.1 Composition:

[0020] (1) Saline agar slant: Dissolve 15g agar powder and 7-8g sodium chloride in 1000ml distilled water, pack them in small test tubes for autoclaving (121°C, 15min), when the agar is cooled to about 75°C, pour it to form inclined plane.

[0021] (2) Erythromycin: Put 0.5g of erythromycin powder for laboratory use in a sterile container, add 20ml of 70% ethanol to dissolve, place at 4°C for more than 2h, and then add sterilized water to 50ml.

[0022] (3) Rice noodles: japonica rice noodles are sterili...

Embodiment 2

[0036] Example 2. Clinical trial of using amoeba histolytica as a bioknife for localized resection of hepatic malignant solid tumors

[0037] Clinically diagnosed patients with primary localized liver cancer, after positioning by B-ultrasound, CT, and MRI scans, the virulent Entamoeba histolytica trophozoites 10 5 ~10 6 / ml 5-10ml / inject into the center of the liver tumor, and after 2-3W, hepatic amoebic abscess will be formed in the liver cancer site (observed by B-ultrasound). When the level of liver cancer markers (AFP) in the blood is normal, it can be considered that the liver tumor has been biologically resected, and local drainage and local injection of anti-amoeba drugs are started. Cure amebic liver abscess, and finally achieve the goal of clinical or complete cure of malignant tumors.

Embodiment 3

[0038] Example 3. Clinical trial of using histolytic amoeba as a bioknife to resect malignant solid tumors of the lung

[0039] Clinically diagnosed patients with primary localized lung cancer, after positioning by B-ultrasound, CT, and MRI scans, the virulent Entamoeba histolytica trophozoites 10 5 ~10 6 / ml 5-10ml / inject into the central part of the lung tumor, after 2-3W, a pulmonary amoebic abscess will be formed in the lung cancer site (observed by X-ray). Light, CT, MRI inspection), it can be considered that the liver tumor has been biologically resected, and local drainage and local injection of anti-amoeba drugs are started. At the same time, systemic anti-amoeba, anti-bacterial therapy and other support nutrition therapy are used to cure the amoeba. Pakistan lung abscess, and finally achieve the goal of clinical or complete cure of malignant tumors.

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PUM

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Abstract

An application of the toxic histolytic ameba in treating the malignant solid tumor is disclosed, which features that said toxic histolytic ameba is used as the biologic knife to excise malignant solid tumor.

Description

(1) Technical field: [0001] The invention relates to the application of histolytic amoeba, in particular to the application of histolytic amoeba in the treatment of malignant solid tumors. (two) background technology: [0002] Tumor is one of the common diseases that threaten human health, second only to cardiovascular disease, and its incidence is increasing year by year. At present, the clinical treatment of tumors mostly adopts comprehensive treatment based on surgery, including chemotherapy, physical therapy (radiation, ultrasound, hyperthermia, low temperature technology, etc.), biological therapy, and traditional Chinese medicine treatment, but none of them are ideal. Surgical treatment of cancer patients causes great damage and is easy to transfer. Radiotherapy and chemotherapy can easily kill the patient's normal tissue and destroy the patient's immune system, reducing the patient's resistance. Moreover, the patient's treatment costs are high, the curative effect is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K39/002A61P35/00
Inventor 徐庆罗伟生程训佳李勇文戴之凯梁荣感李利亚简洁韦京辰黄春松龚受基梁成钦
Owner GUILIN MEDICAL UNIVERSITY
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