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Lyophilized powder injection of breviscapinum and preparation process thereof

A technology for freeze-dried powder injection and breviscapine, which is applied to breviscapine for injection, scutellarin for injection, mannitol and sodium bicarbonate, and the field of breviscapine, which can solve the problem of poor formability of breviscapine and breviscapine. Problems such as poor solubility and difficulty in prescription research can achieve the effect of improving and treating blood circulatory system diseases, with remarkable efficacy and stable and reliable products.

Inactive Publication Date: 2010-04-21
王锦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is that breviscapine has poor formability, and breviscapine has poor solubility, and it is a flavonoid glycoside compound, so there are certain difficulties in prescription research

Method used

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  • Lyophilized powder injection of breviscapinum and preparation process thereof
  • Lyophilized powder injection of breviscapinum and preparation process thereof
  • Lyophilized powder injection of breviscapinum and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prescription (1000 sticks)

[0027] Breviscapine 50g(50.25%)

[0028] Mannitol 40g (40.20%)

[0029] Sodium bicarbonate 9.5g (9.55%)

[0030] Product specification: 50mg / bottle

[0031] Process: Under the condition of 10,000 grades, take the above-mentioned qualified breviscapine raw materials for injection (self-inspection increases heat source, abnormal toxicity, hemolysis, etc.) and auxiliary materials and dissolve them in 1800ml of water for injection. After decolorization, add Dilute with water for injection to a total volume of 2000ml. First filter with fast filter paper, then filter the filtrate through filter paper and 0.45μm filter membrane, and then filter it with a filter membrane below 0.2μm under the condition of 100 grades. Cover with a slotted lid, send it to a freezer vacuum dryer, quickly cool to -35°C ~ -40°C, take 2 to 3 hours, gradually heat up to 35°C ~ 45°C, tighten the lid, take out the product, cover and pack , Inspection, and qualified medi...

Embodiment 2

[0034] Prescription (1000 sticks)

[0035] Breviscapine 50g(47.17%)

[0036] Mannitol 46g (43.40%)

[0037] Sodium bicarbonate 10g (9.43%)

[0038] Product specification: 50mg / bottle

[0039] Technology: technology requirement and process are basically the same as embodiment 1.

Embodiment 3

[0041] Prescription (1000 sticks)

[0042] Breviscapine 55g (47.21%)

[0043] Mannitol 50g (42.92%)

[0044] Sodium bicarbonate 11.5g (9.87%)

[0045] Product specification: 50mg / bottle

[0046] Technology: technology requirement and technological process are basically the same as embodiment 1.

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Abstract

The invention relates to a lamp-dish flower freeze dried injection, wherein it comprises lamp-dish flower at 45-57%, 35-47% mannidex, and 8-12% bicarbonate. It has high stability, and since it has high lamp-dish flower content, it has better activate blood circulation and remove stasis functions, with simple application. Via cute toxic test, its LD50 is higher than prevent lamp-dish flower. The invention can improve treatment effect on blood circulation diseases, etc.

Description

technical field [0001] The invention relates to a breviscapine for injection for treating cardiovascular and cerebrovascular diseases, more precisely, relates to a breviscapine for injection containing breviscapine, mannitol and sodium bicarbonate and a production method thereof, belonging to biotechnology field. Background technique [0002] Erigeron breviseapus is mainly produced in Dali, Wenshan, Honghe and other places in Yunnan. .) Hand.-Mazz] dried whole herb. Yunnan folks call it Erigeron breviscapus, Erigeron elegans, and Asarum esophagus. Breviscapine is a flavonoid compound isolated from Erigeron breviscapine, the main component is scutellarin, and it also contains a small amount of breviscapine A. Varieties such as injections, tablets or powder injections made of breviscapine have all met national standards. The implementation standard is WS 3 -B-3822-98,WS 3 -B-3879-98 etc. Breviscapine is a botanical medicine discovered during the vigorous development of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/19A61P9/00
Inventor 任杨帆
Owner 王锦
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