Pharmaceutical composition containing ligustrazine and effective component of ginkgo leaf and formulation thereof
A technology of active ingredients and compositions, applied in the field of pharmaceutical compositions containing ligustrazine and ginkgo biloba active ingredients and preparations thereof, can solve the problem that the content, clarity, and color of the active ingredients are not stable enough, the content of the active ingredients is unstable, and the raw medicinal materials are not stable enough. The quality difference is large and other problems, and the effect of eliminating platelet aggregation, solving drug safety problems and cerebral ischemia is achieved.
Examples
Embodiment 1
[0037] Weigh 2 g of ginkgo biloba and 100 g of ligustrazine phosphate, which can be made into 100,000 ml of liquid medicine, and finally made into 400 bottles of large-capacity injections (the specification is 250 ml / bottle). Add an appropriate amount of water for injection at 85°C to the concentrated preparation tank, put 900g of sodium chloride into the concentrated preparation tank, stir fully to dissolve completely, add activated carbon according to 0.04% of the total volume of the preparation, heat at 90°C, keep it warm for 20 minutes, and cool down to 50 ℃, decarbonize and filter the medicinal solution into the dilute preparation tank, add the above raw materials into the dilute preparation tank, stir fully to dissolve completely, add activated carbon according to 0.02% of the total volume of the preparation, let it stand for 20 minutes, and add water for injection until the preparation is complete. Adjust the pH of the liquid to 4.8±0.2, decarbonize and filter the liquid...
Embodiment 2
[0039] Take ginkgolide A and ginkgolide B total 1g, ligustrazine hydrochloride 150g, can be made into 100000ml liquid medicine, finally make 400 bottles of large-capacity injection (specification is 250ml / bottle). Add an appropriate amount of water for injection at 85°C to the concentrated preparation tank, put 900g of sodium chloride into the concentrated preparation tank, stir fully to dissolve completely, add activated carbon according to 0.04% of the total volume of the preparation, heat at 90°C, keep it warm for 20 minutes, and cool down to 50 ℃, decarbonize and filter the medicinal solution into the dilute preparation tank, add the above raw materials into the dilute preparation tank, stir fully to dissolve completely, add activated carbon according to 0.02% of the total volume of the preparation, let it stand for 20 minutes, and add water for injection until the preparation is complete. Adjust the pH of the liquid to 4.8±0.2, decarbonize and filter the liquid medicine, a...
Embodiment 3
[0041] Weigh 1.2 g of kaempferol-3-O-rhamnoside, bilobalide, and 120 g of ligustrazine phosphate to make 100,000 ml of liquid medicine, and finally make 400 bottles of large-capacity injection (the specification is 250 ml / bottle). Add an appropriate amount of water for injection at 85°C to the concentrated preparation tank, put 900g of sodium chloride into the concentrated preparation tank, stir fully to dissolve completely, add activated carbon according to 0.04% of the total volume of the preparation, heat at 90°C, keep it warm for 20 minutes, and cool down to 50 ℃, decarbonize and filter the medicinal solution into the dilute preparation tank, add the above raw materials into the dilute preparation tank, stir fully to dissolve completely, add activated carbon according to 0.02% of the total volume of the preparation, let it stand for 20 minutes, and add water for injection until the preparation is complete. Adjust the pH of the liquid to 4.8±0.2, decarbonize and filter the l...
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Description
Claims
Application Information
- IPC
- A61K36/16; A61K31/4965; A61P9/10
- Inventors
- 魏海关