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Pharmaceutical composition containing ligustrazine and effective component of ginkgo leaf and formulation thereof

A technology of active ingredients and compositions, applied in the field of pharmaceutical compositions containing ligustrazine and ginkgo biloba active ingredients and preparations thereof, can solve the problem that the content, clarity, and color of the active ingredients are not stable enough, the content of the active ingredients is unstable, and the raw medicinal materials are not stable enough. The quality difference is large and other problems, and the effect of eliminating platelet aggregation, solving drug safety problems and cerebral ischemia is achieved.

Inactive Publication Date: 2007-05-23
北京天新园医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to the shortcomings of the extraction process and the characteristics of the Chinese medicinal materials, the quality of the above-mentioned ginkgo leaf extracts is difficult to be strictly controlled; in addition, the quality of the original medicinal materials in different origins and different picking seasons is quite different, resulting in the active ingredient content of preparations, especially injection preparations, Clarity and color are not stable enough
Extracts of raw medicinal materials contain unpredictable impurities, which are likely to cause adverse reactions, and there are problems of heavy metals and pesticide residues
The disadvantages of unstable content of active ingredients and the presence of impurities lead to hidden dangers of drug safety in its preparations, especially injections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Weigh 2 g of ginkgo biloba and 100 g of ligustrazine phosphate, which can be made into 100,000 ml of liquid medicine, and finally made into 400 bottles of large-capacity injections (the specification is 250 ml / bottle). Add an appropriate amount of water for injection at 85°C to the concentrated preparation tank, put 900g of sodium chloride into the concentrated preparation tank, stir fully to dissolve completely, add activated carbon according to 0.04% of the total volume of the preparation, heat at 90°C, keep it warm for 20 minutes, and cool down to 50 ℃, decarbonize and filter the medicinal solution into the dilute preparation tank, add the above raw materials into the dilute preparation tank, stir fully to dissolve completely, add activated carbon according to 0.02% of the total volume of the preparation, let it stand for 20 minutes, and add water for injection until the preparation is complete. Adjust the pH of the liquid to 4.8±0.2, decarbonize and filter the liquid...

Embodiment 2

[0039] Take ginkgolide A and ginkgolide B total 1g, ligustrazine hydrochloride 150g, can be made into 100000ml liquid medicine, finally make 400 bottles of large-capacity injection (specification is 250ml / bottle). Add an appropriate amount of water for injection at 85°C to the concentrated preparation tank, put 900g of sodium chloride into the concentrated preparation tank, stir fully to dissolve completely, add activated carbon according to 0.04% of the total volume of the preparation, heat at 90°C, keep it warm for 20 minutes, and cool down to 50 ℃, decarbonize and filter the medicinal solution into the dilute preparation tank, add the above raw materials into the dilute preparation tank, stir fully to dissolve completely, add activated carbon according to 0.02% of the total volume of the preparation, let it stand for 20 minutes, and add water for injection until the preparation is complete. Adjust the pH of the liquid to 4.8±0.2, decarbonize and filter the liquid medicine, a...

Embodiment 3

[0041] Weigh 1.2 g of kaempferol-3-O-rhamnoside, bilobalide, and 120 g of ligustrazine phosphate to make 100,000 ml of liquid medicine, and finally make 400 bottles of large-capacity injection (the specification is 250 ml / bottle). Add an appropriate amount of water for injection at 85°C to the concentrated preparation tank, put 900g of sodium chloride into the concentrated preparation tank, stir fully to dissolve completely, add activated carbon according to 0.04% of the total volume of the preparation, heat at 90°C, keep it warm for 20 minutes, and cool down to 50 ℃, decarbonize and filter the medicinal solution into the dilute preparation tank, add the above raw materials into the dilute preparation tank, stir fully to dissolve completely, add activated carbon according to 0.02% of the total volume of the preparation, let it stand for 20 minutes, and add water for injection until the preparation is complete. Adjust the pH of the liquid to 4.8±0.2, decarbonize and filter the l...

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Abstract

The invention relates to pharmaceutical composition and relevant preparation containing active constituents of ligustrazine and ginkgo leaves, wherein the compound preparation can act on human body by employing the synergism between the two constituents, and is effective in activating blood circulation, removing stasis, resisting platelet conglomeration, expanding blood vessel, improving microcirculation, thus can be used for preparing medicament for treating ischemic cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a pharmaceutical composition containing effective ingredients of ligustrazine and ginkgo biloba and a preparation thereof. technical background [0002] Ligustrazine is an alkaloid monomer extracted from the traditional Chinese medicine Ligusticum chuanxiong, and its hydrochloride and phosphate are commonly used. Ligustrazine hydrochloride and ligustrazine phosphate are white or off-white crystalline powders, which can dilate blood vessels, increase coronary blood flow, cerebral blood flow and improve microcirculation, increase myocardial contractility, and prevent and treat ischemia, hypoxia and reperfusion. Pharmacological effects such as cell damage. Ligustrazine is rapidly absorbed and excreted, and can pass through the blood-cerebrospinal fluid barrier. Clinically used for ischemic cerebrovascular diseases (such as cerebral insufficiency, cerebral thrombosis, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K31/4965A61P9/10
Inventor 魏海关
Owner 北京天新园医药科技开发有限公司
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