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Hawthorn leaf total flavone sustained-release tablet and its preparing method

A technology of total flavonoids and hawthorn leaves, which is applied in the field of preparation of total flavonoids from hawthorn leaves sustained-release tablets, can solve the problems of inconvenience in medication, achieve the effects of overcoming peak and valley fluctuations, reducing toxic and side effects, and reducing drug release speed

Inactive Publication Date: 2007-06-13
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But take medicine 3 times every day, clinical patient especially senile patient's medicine has inconvenience more, so the present invention will prepare its sustained-release tablet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Hawthorn Leaf Total Flavonoids 144mg

[0025] Hydroxypropyl Methyl Cellulose 90mg

[0026] Croscarmellose Sodium 45mg

[0027] Sodium Lauryl Sulfate 9mg

[0028] Magnesium Stearate 1.5mg

[0029] 90% ethanol appropriate amount

[0030] Pass the total flavonoids of hawthorn leaves, hydroxypropyl methylcellulose, sodium lauryl sulfate, and croscarmellose sodium through a 60-mesh sieve and mix well. Add 90% ethanol to make a soft material, pass through a 16-mesh sieve to granulate, granulate after drying, add magnesium stearate, mix evenly, press into tablets, and coat to make Yixinone sustained-release tablets.

[0031] The Yixindone sustained-release tablets prepared in this example contain no less than 0.46 mg of flavonoids in terms of hyperin. The dissolution test is shown in Table 1.

[0032] Table 1 Dissolution comparison between Yixindone sustained-release tablets and ordinary tablets

[0033] time (hours)

[0034] As can be seen from the results in...

Embodiment 2

[0036] Hawthorn Leaf Total Flavonoids 144mg

[0037] Hydroxypropyl Methyl Cellulose 120mg

[0038] Croscarmellose Sodium 60mg

[0039] Sodium Lauryl Sulfate 10mg

[0040] Magnesium Stearate 2mg

[0041] 90% ethanol appropriate amount

[0042] Pass the total flavonoids of hawthorn leaves, hydroxypropyl methylcellulose, sodium lauryl sulfate, and croscarmellose sodium through 60 mesh and mix thoroughly. Add 90% ethanol to make a soft material, pass through a 16-mesh sieve to granulate, granulate after drying, add magnesium stearate, mix evenly, press into tablets, and coat to make Yixinone sustained-release tablets.

[0043] The Yixindone sustained-release tablets prepared in this example contain no less than 0.46 mg of flavonoids in terms of hyperin. The dissolution test is shown in Table 2.

[0044] Table 2 Dissolution comparison between Yixindone sustained-release tablets and ordinary tablets

[0045] time (hours)

[0046] As can be seen from the results in t...

Embodiment 3

[0048] Hawthorn Leaf Total Flavonoids 144mg

[0049] Hydroxypropyl Methyl Cellulose 75mg

[0050] Croscarmellose Sodium 30mg

[0051] Sodium Lauryl Sulfate 9mg

[0052] Magnesium Stearate 1.5mg

[0053] 90% ethanol appropriate amount

[0054] Pass the total flavonoids of hawthorn leaves, hydroxypropyl methylcellulose, sodium lauryl sulfate, and croscarmellose sodium through 60 mesh and mix thoroughly. Add 90% ethanol to make a soft material, pass through a 16-mesh sieve to granulate, granulate after drying, add magnesium stearate, mix evenly, press into tablets, and coat to make Yixinone sustained-release tablets.

[0055] The Yixindone sustained-release tablets prepared in this example contain no less than 0.46 mg of flavonoids in terms of hyperin. The dissolution test is shown in Table 3.

[0056] Table 3 Dissolution comparison between Yixindone sustained-release tablets and ordinary tablets

[0057] time (hours)

[0058] As can be seen from the results in t...

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Abstract

The present invention relates to a crataegus leaf total flavone slow-released tablet. It is made up by using crataegus leaf total flavone as main medicine and adding hydroxypropyl methyl cellulose, cross-linked sodium cellulose glycollate or cross-linked polgvinylpyrrolidone, sodium lauryl sulfate, microcrystalline cellulose and magnesium stearate or micropowder silica gel as auxiliary material through a certain preparation process. Said invention also provides its preparation method.

Description

technical field [0001] The invention relates to a sustained-release tablet of Yixinketone (that is, total flavonoids of hawthorn leaves); the invention also relates to a preparation method of the sustained-release tablet of total flavonoids of hawthorn leaves. Background technique [0002] After modern pharmacy experienced three important stages of physical pharmacy, biopharmaceutical and clinical pharmacy, it entered a new era of Drug Delivery System (DDS) at the end of the 20th century. Long-acting and extended-release formulations, controlled-release formulations, and targeted formulations. In the meantime, although Chinese medicine preparations have made remarkable progress, they are basically still in the stage of conventional preparations, which cannot meet the requirements of modern people for medical preparations in terms of variety and quality. This has become a major obstacle for Chinese medicine to go global. [0003] Sustained-release preparations are popular be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K9/22A61P9/10
Inventor 冯年平曲璐
Owner SHANGHAI UNIV OF T C M
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