Orodispersible pharmaceutical composition for oromucosal or sublingual administration of agomelatine
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- LES LAB SERVIER
- Publication Date
- 2007-06-20
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention relates to novel coated solid orodispersible pharmaceutical dosage forms of agomelatine for administration by oral, oromucosal or sublingual routes. Background technique
[0002] Agomelatine or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide of formula (I):
[0003]
[0004] As well as its hydrates, crystalline forms and pharmaceutically acceptable acid or base addition salts have valuable pharmacological properties: it is a selective agonist for receptors of the melatoninergic system, on the other hand it is a 5- HT 2C Antagonist of the receptor, which makes it active in the central nervous system. These properties provide it with activity in the central nervous system, especially in the treatment of major depression, seasonal affective disorder, sleep disturbances, cardiovascular diseases, digestive disorders, insomnia and fatigue due to jet lag, appetite disorders and obesity active in.
[0005] Agomelatine, its preparation a...