Medicine composition of glycyrrhizic acid or its salt and reduced glutathione

A technology of glutathione and composition, which is applied in the field of medicine to achieve the effects of ensuring safety, definite curative effect and reducing relative dosage

Inactive Publication Date: 2010-05-12
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the interaction between glycyrrhizic acid or its pharmaceutically acceptable salt and reduced glutathione, compatible prescriptions, and drugs for the treatment of liver diseases have not been reported.

Method used

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  • Medicine composition of glycyrrhizic acid or its salt and reduced glutathione
  • Medicine composition of glycyrrhizic acid or its salt and reduced glutathione

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] The preparation of embodiment 1 Gan Gu composition powder injection

[0102] 1. Prescription:

[0103] Composition prescription of Gan Gu 1

[0104] Monoammonium Glycyrrhizinate 40g

[0105] Reduced Glutathione 300g

[0106] Glycine 400g

[0107] Cysteine ​​Hydrochloride 20g

[0108] Mannitol 300g

[0109] Add sterile water for injection to 3000ml

[0110] A total of 1000 sticks were prepared

[0111] Gan Gu Composition Prescription 2

[0112] Diammonium Glycyrrhizinate 150g

[0113] Reduced Glutathione 300g

[0114] Mannitol 300g

[0115] Add sterile water for injection to 3000ml

[0116] A total of 1000 sticks were prepared

[0117] 2. Specific steps:

[0118] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0119] 2) Weigh the raw materials and auxiliary materials according to the prescription quantity.

[0120] 3) Take sterile water for injection with a dosing volume of 80%, ad...

Embodiment 2

[0128] Example 2 Preparation of Gan Gu Composition Aqueous Injection

[0129] 1. Prescription:

[0130] Gan Gu composition prescription 1

[0131] Monoammonium Glycyrrhizinate 40g

[0132] Reduced Glutathione 300g

[0133] Glycine 400g

[0134] Cysteine ​​Hydrochloride 20g

[0135] Add water for injection to 10000ml

[0136] A total of 1000 sticks were prepared

[0137] Kangu Composition Prescription 2

[0138] Diammonium Glycyrrhizinate 150g

[0139] Reduced Glutathione 300g

[0140] Add water for injection to 10000ml

[0141] A total of 1000 sticks were prepared

[0142] 2. Specific steps:

[0143] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0144] 2) Take 80% of the water for injection, add the prescribed amount of monoammonium glycyrrhizinate (or diammonium glycyrrhizinate) and reduced glutathione, add amino acids according to the prescription, heat and stir...

Embodiment 3

[0153] Example 3 Preparation of Sodium Chloride Infusion of Sugar Grain Composition

[0154] 1. Prescription:

[0155] Composition prescription of Gan Gu 1

[0156] Monoammonium Glycyrrhizinate 40g

[0157] Reduced Glutathione 300g

[0158] Glycine 400g

[0159] Cysteine ​​Hydrochloride 20g

[0160] Sodium chloride 900g

[0161] Add water for injection to 100000ml

[0162] A total of 1000 bottles were prepared

[0163] Gan Gu Composition Prescription 2

[0164] Diammonium Glycyrrhizinate 150g

[0165] Reduced Glutathione 300g

[0166] Sodium chloride 900g

[0167] Add water for injection to 100000ml

[0168] A total of 1000 bottles were prepared

[0169] 2. Specific steps:

[0170] 1) Dispose of the pipes and containers used for liquid preparation the day before, and rinse them with fresh water for injection before use.

[0171] 2) Add monoammonium glycyrrhizinate (or diammonium glycyrrhizinate) and reduced glutathione to water for injection with a dosing volum...

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Abstract

The present invention belongs to the field of medicine technology, and is especially one medicine composition for treating liver diseases and its preparation process and use. The medicine compositionconsists of glycyrrhizic acid or its pharmaceutically acceptable salt 4-800 weight portions, and reductive glutathione 75- 1500 weight portions. The pharmaceutically acceptable salt of glycyrrhizic acid may be metal salt or organic nitrogen salt. The medicine composition may be prepared into different forms. The medicine composition has the synergistic effect of the components in treating liver diseases, high stability, and wide application.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition mainly made of glycyrrhizic acid or a pharmaceutically acceptable salt thereof and reduced glutathione and a preparation method thereof, belonging to the technical field of medicine. 2. Background technology [0002] Hepatitis is one of the common serious infectious diseases, among which viral hepatitis is the main one. According to incomplete statistics, currently 8-10% of the Chinese population are carriers of hepatitis B virus, and there are still a considerable number of new patients increasing every year. Viral hepatitis can be divided into types: acute hepatitis, chronic hepatitis, severe hepatitis and biliary hepatitis. Severe hepatitis can lead to liver cirrhosis, liver cancer and other diseases. Although there are many kinds of drugs for treating liver diseases at present, because the pathogenesis of liver diseases has not been fully elucidated, most of them are drugs that improve liver...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/06A61P1/16A61P31/14A61P31/20A61K31/704
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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