Method for preventing hormone induced adverse effects

a technology of adverse effects and hormones, applied in the field of prevention of hormone induced adverse effects, can solve the problems of increasing the risk of osteoporosis and coronary heart disease, estrogens are positively correlated with an increased risk of endometrial cancer development, and diminishing the beneficial effects of estrogen on the plasma lipid profile, so as to prevent the adverse effects and increase the risk of developing cancer

Inactive Publication Date: 2001-10-04
LYCORED NATURAL PRODS INDS
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  • Description
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Benefits of technology

0016] The present invention provides a method for preventing the adverse effects which may be associated with the administration of at least one hormone to a subject without detectable cancer comprising administering to such subjec

Problems solved by technology

Reduced levels of circulating estrogen in post-menopausal women are also associated with increased risks of osteoporosis and coronary heart disease.
In contrast with this beneficial effect, long-term use of estrogens is positively correlated with an increased risk for endometrial cancer development.
This form of combination therapy however, apparently diminishes the beneficial effects of estrogen on the plasma lipid profile (Lobo R.
Furthermore, some progestins are associated with an increased risk of mammary cancer de

Method used

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  • Method for preventing hormone induced adverse effects
  • Method for preventing hormone induced adverse effects
  • Method for preventing hormone induced adverse effects

Examples

Experimental program
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Effect test

example 2

[0058] Inhibitory Effect of Lycopene on Both Genistein and Estradiol Stimulation of Hormone-dependent Malignant Cells.

[0059] The comparative effects of estradiol and genistein supplementation on the proliferation of the hormone-dependent cell lines MCF-7 mammary cancer and ECC-1 endometrial cancer were examined (FIG. 2). In each of these cell lines, genistein exhibited biphasic effects on proliferation, stimulating at low concentrations and inhibiting at high concentrations (FIG. 2, panel A), as demonstrated in Example 1. Estradiol at each of the concentrations tested (1 and 10 nM) was only stimulatory for cell growth (FIG. 2 , panel B). These results suggest that the stimulatory effect of genistein may be due to its estrogenic action.

[0060] Cell cultures stimulated either by genistein or estradiol, as described above, were further supplemented with lycopene and assayed for cell proliferation after three days in culture. As shown in FIG. 2, lycopene supplementation at 3 to 5 .mu.M s...

example 3

[0061] Inhibitory Effect of Lycopene on IGF-1-stimulated Growth in Hormone-Dependent and Hormone-independent Mammary Cancer Cells.

[0062] FIG. 3 shows that IGF-1 (30 nM) supplementation of both hormone-dependent MCF-7 mammary cancer cells (panel A) and hormone-independent MDA-231 mammary cancer cells (panel B) significantly stimulates cell growth. In MCF-7 cells, the stimulatory effect of genistein is further augmented in the presence of IGF-I (FIG. 3, panel A). MDA-231 is stimulated by IGF-I, but not by genistein. Thus genistein not only stimulates hormone-dependent cancer cell proliferation, but IGF-I as well as other growth factors further augment this effect.

[0063] Cell cultures supplemented as above were further supplemented with lycopene at 3 to 5 .mu.M concentration. As shown in FIG. 3, lycopene inhibits IGF stimulation in both hormone-dependent and hormone-independent mammary cancer cell lines. In the case of MDA-231 cells, cell proliferation was reduced to levels less than t...

example 4

[0064] Inhibitory Effects of Carotenoids on Estradiol and Genistein Induced Proliferation of ECC-1 Cells.

[0065] The ECC-1 hormone-dependent cell line was stimulated either by estradiol at 10 nM (FIG. 4, left panel) or by genistein at 1 .mu.M (FIG. 4, panel B) and test cultures were additionally supplemented with various carotenoids. The results demonstrate that all carotenoids tested (lycopene, beta-carotene, astaxanthin and a mixture of phytoene and phytofluene) effectively inhibited both estradiol- and genistein-induced cell proliferation.

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Abstract

The present invention provides a method for preventing the adverse effects which may be associated with the administration of at least one hormone to a subject without detectable cancer comprising administering to such subject at least one carotenoid. The invention further provides a method for preventing a variety of adverse effects associated with the administration of hormones, including, for example, an increased risk for developing cancer. The invention further provides a method for preventing adverse effects without inhibiting the beneficial activity of the hormone. The invention further provides a method for preventing the adverse effects associated with administration of estrogen and/or progestin in hormone replacement therapy without inhibiting the beneficial activity of such hormone. The invention further provides a method for preventing the adverse effects associated with the administration of phytoestrogens. The invention further provides a method for preventing adverse effects associated with the administration of phytoestrogens without inhibiting the beneficial activity of such hormone.

Description

[0001] The present invention provides a method for preventing adverse effects associated with the administration of hormones such as phytoestrogens and steroidal estrogens.[0002] Hormone intake by humans can occur through, inter alia, consumption of pharmaceutical compositions, foodstuffs, nutritional supplements, and nutraceuticals. Such hormones include phytoestrogens, or nonsteroidal estrogens, steroidal estrogens and progestins. Phytoestrogens comprise, for example, genistein, daidzein and glycitein, and their respective glucoside, malonylglucoside and acetylglucoside derivatives. Estrogens and progestins are known to be used for hormone replacement therapy (HRT) and in contraceptive medications. HRT with estrogens or with estrogen / progestin combinations has been the standard method for treating symptoms associated with menopause (Emster V L et al. (1988) Benefits and Risks of Menopausal Estrogen and / or Progestin Hormone Use, Prev. Med. 17:201-223). The onset of menopause in mat...

Claims

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Application Information

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IPC IPC(8): A61K31/00A61K31/01A61K31/015A61K31/045A61K31/047A61K31/07A61K31/12A61K31/122A61K31/353A61K31/56A61K31/565A61K31/566A61K31/567A61K31/57A61K31/7048A61K33/24A61K36/185A61K38/24A61P5/30A61P9/10A61P15/12A61P15/18A61P19/10A61P35/00A61P43/00
CPCA61K31/015A61K31/07A61K31/56A61K31/565A61K31/57A61K33/24A61K36/185A61K31/12A61K31/01A61K2300/00A61P15/12A61P15/18A61P19/10A61P35/00A61P43/00A61P5/30A61P9/10
Inventor LEVY, JOSEPHSHARONI, YOAV
Owner LYCORED NATURAL PRODS INDS
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