Fluid therapy with l-lactate and/or pyruvate anions

a technology of pyruvate anions and fluoride, which is applied in the field of human fluoride therapy, can solve the problems of death, worsening of cerebral edema, and d-form has now been discovered to cause adverse and toxic effects,
US20050058724A1Inactive Publication Date: 2005-03-17BTG INT LTD
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BTG INT LTD
Publication Date
2005-03-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

Electrolyte solutions are provided which are useful in electrolyte and fluid therapy, parenteral nutrition and dialysis. The Na:Cl ratio is normalized, plasma and cellular pH are normalized and cellular cofactor ratios are normalized in a manner which decreases toxicity over prior art solutions.
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Description

BACKGROUND OF THE INVENTION 1. Field of the Invention This invention lies in the field of fluid therapy in humans, and more particularly in the field of aqueous solutions for parenteral, oral, dialysis, and irrigation therapy which employ at least one of 1-lactate anions, pyruvate anions, d-betahydroxybutyrate anions, acetoacetate anions, or mixtures thereof in combination with selected cations. 2. Prior Art Previously, I have provided improved electrolyte solutions for in vivo and in vitro usage which contain 1-lactate and pyruvate anions, and / or d-betahydroxybutyrate and acetoacetate anions in respective defined ratios in combination with defined Na:Cl ratios; see my copending U.S. patent applications Serial Nos. 748,232 and 747,792, both filed Jun. 24, 1985, and also my copending U.S. patent application Serial Nos. 747,858 and 748,184, also filed on such date. However, it is now appreciated that the benefits of using 1-lactate, pyruvate, d-betahydroxybutyrate, and / or acetoace...

Claims

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