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Athermal process for the concentration of Garcinia extract

a technology of garcinia extract and thermal process, which is applied in the directions of plant/algae/fungi/lichens, unknown materials, biocide, etc., can solve the problems of reducing the solubility and subsequently bioavailability of garcinia extract, affecting the taste of garcinia extract, and requiring too many unit operations to obtain the final product, etc., to achieve an efficient and economical process. , the effect of simple single step

Inactive Publication Date: 2005-06-23
COUNCIL OF SCI & IND RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010] Yet another object of present invention is to provide a simple single step and efficient economical process for the concentration of HCA, wher it is present in its native form.

Problems solved by technology

The fruits from both the species of Garcinia are not palatable due to their strong acid taste.
But the excess calcium reduces the solubility and subsequently bioavailability when it is compared to the liquid extract.
The main drawback of this method is the thermal process and also it involves too many unit operations for obtaining the final product.
The main drawback of this method is the potassium salt is hygroscopic.
Further, HCA is not available in natural state, limiting its bioavailability and versatile applicability for pharmaceutical purposes.
But, there is no report on non-thermal process for concentrating of HCA and also in its native (not as derivatives) form.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example-1

[0035] Fruit rinds of G. pedunculata in 500 g quantity were cut into small pieces and extracted with 1.5 liters of de-ionized water for a period of 20 min at 120° C. The above extract was filtered through filter cloth. The extract was taken and subjected to concentration by osmotic membrane distillation in a co-current flat membrane module using micro porous hydrophobic polypropylene membrane of 0.05 μm at a flow rate of 100 ml / min. The module was operated in co-current mode using saturated calcium chloride as osmotic agent. The concentration was carried out till the volume of the extract was reduced to ⅕ of the original volume. The concentration of HCA had increased from 6 to 62° Brix. The HCA content was determined by HPLC method and the acid was found to be 33.58% from an initial content of 5.09%. (6 fold enhancement).

example-2

[0036] Fruit rinds of G. cowa in 1000 g quantity were cut into small pieces and extracted with 3 liters of de-ionized water for a period of 30 min at 130 psi using autoclaving. The extract was filtered through filter cloth. The extract was taken and subjected to concentration by osmotic membrane distillation in a co-current flat membrane module using micro porous hydrophobic polypropylene membrane of 0.05 μm at a flow rate of 130 ml / min. The module was operated in co-current mode using saturated calcium chloride as osmotic agent. The concentration was carried out till the volume of the extract was reduced to {fraction (1 / 5)}th of the original volume. The concentration of HCA had increased from 6 to 62° Brix. The HCA content was determined by HPLC method and the acid was found to be 35.5% from an initial content of 6%. (7 fold enhancement).

example-3

[0037] Fruit rinds of G. pedunculata in 100 gm quantity were cut into small pieces and extracting with 1 liter of de-ionized water for a period of 50 min at 120° C. using autoclaving. The extract was filtered through filter cloth. The extract was taken and subjected to concentration by osmotic membrane distillation in a co-current flat membrane module using micro porous hydrophobic polypropylene membrane of 0.05 μm at a flow rate of 150 ml / min. The module was operated in co-current mode using saturated calcium chloride as osmotic agent. The concentration was carried out till the volume of the extract was reduced to ⅕th of the original volume. The concentration of HCA had increased from 6 to 62° Brix. The HCA content was determined by HPLC method and the acid was found to be 34.5% from an initial content of 5%. (6 fold enhancement).

[0038] The main advantages of the present invention are [0039] 1. This is a simple and single step process for obtaining the concentrated free HCA. [0040...

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Abstract

The present invention relates to an athermal process of obtaining concentrated Garcinia extract by using osmotic membrane distillation (OMD).

Description

FIELD OF THE INVENTION [0001] The present invention relates to an athermal process for the concentration of Garcinia extract. The present invention particularly relates to a process of obtaining concentrated Garcinia extract by using osmotic membrane distillation (OMD). BACKGROUND OF THE INVENTION [0002] As dietary supplement, (−)-Hydroxcitic acid (HCA) is an effective agent to any weight management program. Allison et al. (Crit.Rev.Food Sci.Nutr. 2001, 41,1-28) has reviewed the use of HCA as one of the alternative treatments for weight loss. The derivatives of HCA have been incorporated into many pharmaceutical preparations in combination with other ingredients for the purpose of enhancing weight loss, cardioprotection, correcting the conditions of lipid abnormalities and endurance(Jena et al., 2002, J. Agric. Food Chemistry, 50,10-22). So far HCA has been found in the fruits of certain species of Garcinia, which includes G. cambogia, G. indica, G.atroviridis and G. cowa (Lewis, Y....

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/00
CPCB01D61/364A61K36/38
Inventor RAMAKRISHNAN, CHINNASWAMY ANANDHANAGARAJ, NAVEENJAYAPRAKASHA, GUDDADARANGAVVANAHALLY KRISHNAREDDYJENA, BHABANI SANKARVARADARAJ, MANDYAM CHAKRAVARATHYMALLIKARJUNA SRINIVASA RAGHAVARAO, KARUMANCHI SREESAILA
Owner COUNCIL OF SCI & IND RES
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