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Cardiomyopathy treatment device with electrode therapy

a treatment device and electrode technology, applied in the field of biocompatible, biostable and implantable heart sacks, can solve problems such as mechanical abrasion and scar formation

Inactive Publication Date: 2005-08-04
ACORN CARDIOVASCULAR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The heart sack and leads demonstrate excellent biocompatibility and mechanical properties, reducing mechanical abrasion and allowing for effective cardiac pacing or defibrillation, while the semipermeable membrane facilitates fluid flow, addressing the issues of cardiomyopathy and preventing heart damage.

Problems solved by technology

However, the ordinary pacemaker leads that interface with the exterior of the heart often lack physical and physiological compliance with the heart to muscle and its surrounding tissue resulting in mechanical abrasion and scar formation.

Method used

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  • Cardiomyopathy treatment device with electrode therapy
  • Cardiomyopathy treatment device with electrode therapy
  • Cardiomyopathy treatment device with electrode therapy

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0015] A heart shaped polypropylene model including all blood vessel components was coated with a 10% solution of Pellethane 90AE in N-dimethylpyrrolidone and dried. The process was repeated three times to obtain an adequate coating thickness. Then, a screen made of poly(ethylene terephthalate) (PET) was placed onto the coated model and coated again with the Pellethane solution. Coating and drying were repeated several times. Then, the heart shaped skin was removed from the model by making a slit from the center upper edge to below the aorta to obtain a heart shaped sack. Then, a number of polypropylene sutures were attached on the both side of the slit. The sutures make it easier to dose the slit and secure the heart sack on the heart.

example 2

[0016] A heart shaped polypropylene model including all blood vessel components was coated with a polyurethane solution prepared from polytetramethylene ether glycol having a molecular weight of 1,000, methylene bis-phenylisocyanate, and ethylenediamine in dimethylacetoamide and dried. The process was repeated two times to obtain an adequate coating thickness. Then, a screen made of poly(ethylene terephthalate) (PET) was placed onto the coated model and coated again with the Pellethane solution. Coating and drying were repeated several times. Then, the heart shaped skin was removed from the model by making a slit from the center upper edge to below the aorta to obtain a heart shaped sack. Then, a number of polypropylene sutures were attached on the both side of the slit. The sutures make it easier to dose the slit and secure the heart sack on the heart.

example 3

[0017] To the Pellethane solution of example 1, two percent of polyethylene glycol having molecular weight of 1000 was dispersed. Then, the solution was applied to the polypropylene heart model in the same manner. The coating was dried and annealed. Thus obtained heart sack was placed in 60° C. water bath for 60 minutes to leach out the polyethylene glycol. After drying a heart sack with a semipermeable membrane was obtained.

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PUM

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Abstract

This invention relates to implantable heart sack that can be equipped with pacemaker leads and / or defibrillation leads for the treatment of cardiomyopathy, hypertrophic cardiomyopathy tachycardia, bradycardia, ventricular fibrillation, atrial fibrillation etc. The hear sack was prepared from biocompatible, biostable, implantable polyetherurethane, polycarbonateurethane, silicone, polysiloxaneurethane, polyfluoroethylene, or hydrogenated poly(styrene-butadiene) copolymer. The heart sack is equipped with attached sutures to make it easier to attach onto the heart. The heart sack can be made semipermeable or perforated to have numerous holes. The heart sack can be reinforce with fiber or filament. Ordinary pacemaker leads can be attached to the inner side of the heart sack. However, the pacemaker leads of this invention were prepared from noble metal (gold, platinum, rhodium and platinum-Rhodium alloys) or stainless steel coated, deposited or plated mono-filaments, yarns, braids, cords, wires or films, or cylindrical tubes of polyamide, polyimide, polyester, and / or polypropylene that are encased in multi-lumen insulating tube or coaxial tube made of biocompatible, biostable, implantable polyetherurethane, polycarbonateurethane, silicone, polysiloxaneurethane, polyfluoroethylene, or hydrogenated poly(styrene-butadiene) copolymer. The leads can be mounted onto the inner surface of the heart sack and contoured to the heart. The heart sack can be coated with hydrophilic coating containing an antimicrobial agent that gives the heart sack a low coefficient of friction, excellent biocompatibility and antimicrobial properties.

Description

FIELD OF THE INVENTION [0001] This invention relates to a biocompatible, biostable and implantable heart sack which is prepared from biocompatible, biostable and implantable elastomers selected from the group consisting of polyetherurethane, polycarbonateurethane, silicone, poly(siloxane) urethane and / or hydrogenated poly (styrene-butadiene) copolymer for the treatment of cardiomyopathy, hypertrophic cardiomyopathy, tachycardia, bradycardia, ventricular fibrillation, atrial fibrillation etc. The heart sack of this invention can be reinforced with mono-filaments, yarns, braids, cords, knitted or woven or non-woven cloth made of a biocompatible, biostable, implantable polyamide, polyimide, polyester, polypropylene, and / or polyurethane etc. [0002] The heart sack of this invention can be equipped with pacemaker leads and defibrillation leads. The leads and electrodes of this invention are made of noble metal or stainless steel deposited, coated or plated mono-filaments, yarns, braids, c...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N1/05
CPCA61N1/0587
Inventor OKUZUMI, YUZI
Owner ACORN CARDIOVASCULAR