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Method and composition for burned skin

a technology of burnt skin and composition, applied in the field of compositions, methods and delivery systems, can solve the problems of reducing blood perfusion and tissue necrosis, progressing ischemic damage to skin tissue, etc., and achieve the effect of inhibiting the rejection of skin implants

Inactive Publication Date: 2005-09-08
YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0041] In another embodiment, the invention provides a method for reducing the level of a cytokine, interleukin, tumor necrosis factor, IL1 or IL6 in an inflicted skin area comprising the step of contact the inflicted or preinflicted area with an effective amount of a composition comprising ethyl and / or isopropyl alcohol, wherein the ethyl and / or isopropyl alcohol is in a concentration of 15-70%.
[0042] In another embodiment, the invention provides a method for reducing the level of a cytokine, interleukin, tumor necrosis factor, IL1 or IL6 in an inflicted skin area comprising the step of contact the inflicted or preinflicted area with an effective amount of a composition comprising ammonium hydroxide.
[0043] In another embodiment, the invention provides a method for reducing the level of a cytokine, interleukin, tumor necrosis factor, IL 1 or IL6 in an inflicted skin area comprising the step of contact the inflicted or preinflicted area with an effective amount of a composition comprising ammonium hydroxide and ethyl or isopropyl alcohol, wherein the ethyl and / or isopropyl alcohol is in a concentration of 15-70%.

Problems solved by technology

These responses lead to progressive ischemic damage to the skin tissue, reduced blood perfusion and tissue necrosis.

Method used

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  • Method and composition for burned skin
  • Method and composition for burned skin
  • Method and composition for burned skin

Examples

Experimental program
Comparison scheme
Effect test

example 1

Composition 1: a Carbomer Gelled Matrix Containing Ethanol 35% w / w.

[0146] Composition 1 was applied to a second degree burn (as a result of short contact with 175° C. hot oven) on the skin of left hand of a 30 years aged female and remained for about one hour. This treatment completely impeded the development of the burn.

example 2

Composition To Stop Burn Wound Progress

[0147]

% w / wEthanolic plant extracts10Ammonium hydroxide 10% solution2Ethyl alcohol22Carbomer1DDW65

example 3

Composition to Stop Burn Wound Progress

[0148]

% w / wAmmonium hydroxide 10% solution3Alcoholic Aloe Vera Gel57Carbopol 9341Purified water to100%Total ethanol 20%

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Abstract

This invention relates to compositions, methods and delivery systems for application on burns and surrounding tissue wherein said composition comprise ammonium hydroxide (or ammonium bicarbonate) and / or 15-70% volatile short chain mono-alcohols.

Description

FIELD OF THE INVENTION [0001] This invention relates to compositions, methods and delivery systems for application on burns and surrounding tissue wherein said composition comprise ammonium hydroxide (or ammonium bicarbonate) and / or 15-70% volatile short chain mono-alcohols BACKGROUND OF THE INVENTION [0002] Thermal burn injury induces non-specific inflammatory reaction generating dermal vascular damage, destruction of epidermis, edema and blister formation. These responses lead to progressive ischemic damage to the skin tissue, reduced blood perfusion and tissue necrosis. Since not all the skin tissues are immediately destroyed after thermal burn, depth of burns progresses with time. Cytokines IL6, IL1, TNF alpha, other pro-inflammatory interleukins and globulins are important factors in the development of microvascular injury and wound development in burned skin and tissue. Numerous attempts to favorably alter the burn wound by pharmacologic agent are generally of moderate effici...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/34A61K8/81A61K9/00A61K31/045A61K31/78A61K47/02A61K47/10A61K47/32A61Q19/00
CPCA61K9/0014A61K31/045A61K47/10A61K47/02A61K31/78A61P17/02
Inventor TOUITOU, ELKA
Owner YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD