Method and composition for burned skin
Patent Information
- Authority / Receiving Office
- US Ā· United States
- Patent Type
- Applications(United States)
- Current Assignee / Owner
- YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD
- Publication Date
- 2005-09-08
- Estimated Expiration
- Not applicable Ā· inactive patent
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Abstract
Description
FIELD OF THE INVENTION
[0001] This invention relates to compositions, methods and delivery systems for application on burns and surrounding tissue wherein said composition comprise ammonium hydroxide (or ammonium bicarbonate) and / or 15-70% volatile short chain mono-alcohols BACKGROUND OF THE INVENTION
[0002] Thermal burn injury induces non-specific inflammatory reaction generating dermal vascular damage, destruction of epidermis, edema and blister formation. These responses lead to progressive ischemic damage to the skin tissue, reduced blood perfusion and tissue necrosis. Since not all the skin tissues are immediately destroyed after thermal burn, depth of burns progresses with time. Cytokines IL6, IL1, TNF alpha, other pro-inflammatory interleukins and globulins are important factors in the development of microvascular injury and wound development in burned skin and tissue. Numerous attempts to favorably alter the burn wound by pharmacologic agent are generally of moderate effici...