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Coolant plant extract compositions containing monomenthyl succinate

a technology of monomenthyl succinate and plant extract, which is applied in the directions of plant/algae/fungi/lichens, food preparation, biocide, etc., can solve the problems that mms cannot be marketed as nature identical and limit the marketing of mms-containing products in some countries

Inactive Publication Date: 2006-03-16
HISERODT RICHARD DWYER +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention is about a plant extract containing monomenthyl succinate that can be used as a coolant. This extract is isolated from plants of the genus Lycium or Mentha, such as Lycium barbarum or Mentha piperita. The method involves mixing plant biomass with a solvent, extracting the mixture, and filtering to remove the plant biomass. The coolant plant extract can be used in food ingredients, food products, and non-food products."

Problems solved by technology

However, MMS can not be marketed as nature identical since its presence in natural sources has not been demonstrated.
This limits the marketing of MMS-containing products in some countries.

Method used

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  • Coolant plant extract compositions containing monomenthyl succinate
  • Coolant plant extract compositions containing monomenthyl succinate
  • Coolant plant extract compositions containing monomenthyl succinate

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Extracts

[0050] Dried L. barbarum fruit was purchased from an Asian food store. Dried M. piperita and L. barbarum leaves were obtained from Plant It Herbs (Athens, Ohio, www.plantitherbs.com).

[0051] Dried L. barbarum fruit was frozen overnight at −25° C. and powdered in a blender. The moisture content of the powder was determined using a Halogen Moisture Analyzer (Mettler HR 73 HMA) and found to be 16.58%. 205 Grams of powder was extracted in a glass soxhlet extractor using 800 mL of 95% ethyl alcohol. The soxhlet extraction continued for 13.5 hours over a period of two days (9 hours on day one and 4.5 hours on day two). The extract was filtered (Whatman filter paper 1) and the filtrate concentrated to 50 grams in a rotary evaporator (Buchi Rotavapor R-124) under vacuum at 55° C. and 100 rpm. The concentrate, on keeping overnight, developed a sediment which was filtered out to yield 25.5 grams of the final product. 1.3 Grams of this extract were diluted with 1.0 mL m...

example 2

LC / MS / MS (SRM) Instrument Conditions

[0059]

InstrumentFinnigan TSQ 7000 (API 2)interfaced to a SpectraSystemP4000 HPLC PumpColumn:Zorbax 5 μm SB-C182.1 mm (ID) × 150 mm,Ser. No: CN 2051Mobile Phase A:H2O (10 mM NH4OAc)Mobile Phase B:CH3OH (10 mM NH4OAc)Gradient:10% B to 100% B in 10 minutes(hold 15 minutes)Flow Rate:0.2 mL / minuteInjection Volume:20 μLIonization Mode:−APCI (SRM)Vaporizer Temperature:300 or 350° C.Heated Capillary200 or 250° C.Temperature:Sheath Gas (N2):70 or 80 psiAuxiliary Gas (N2):0 or 20 (arbitrary units)Coll. Cell (Ar):2 mTCollision Energy:+20 VPrecursor to Product Ion:m / z 255 / 99

example 3

Preparation of Samples for Standard Addition Determination of MMS in M. Piperita Extract

[0060] A 2.37 gram sample of M. piperita extract was diluted with 2.0 mL methanol (sample concentration=0.54 gram / mL assuming dextract=1 gram / mL). A 400 microliter of this solution was added to four vials. Vials 2-4 were spiked with MMS (84 μg / mL) according to Table 1. The data from analysis are plotted in FIG. 9.

TABLE 1M. piperitaMMSMMS(0.54 g / mL)(84 μg / mL)CH3OHequivalentVialμL addedμL addedμL addedppm14000300240010203.9340020107.8440030011.7

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Abstract

The present invention relates to plant extracts containing a monomenthyl succinate for use as a coolant in food and non-food products. Methods for isolating the plant extracts are also provided.

Description

[0001] This application is a continuation of U.S. Ser. No. 10 / 671,411 filed Sep. 24, 2003, which is herein incorporated by reference in its entirety.BACKGROUND OF THE INVENTION [0002] Monomenthyl succinate (MMS), also known as butanedioic acid monomenthyl ester, is a flavor compound utilized for its cooling effects in oral health care products and chewing gum, see U.S. Pat. Nos. 5,725,865 and 5,843,466. MMS is generally recognized as safe (GRAS) for products sold in the United States. Currently, MMS is synthetically produced for commercial use. [0003] However, MMS can not be marketed as nature identical since its presence in natural sources has not been demonstrated. This limits the marketing of MMS-containing products in some countries. Therefore it would be desirable to find a natural source of MMS. SUMMARY OF THE INVENTION [0004] One aspect of the present invention is a plant extract composition containing monomenthyl succinate that is useful as a coolant. The plant extract is pr...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/534A61K9/68A23L27/10A61K8/37A61K8/97A61Q19/00
CPCA23L1/2215A61K8/37A61Q19/00A61K2800/244A61K8/97A23L27/11A61K8/9789
Inventor HISERODT, RICHARD DWYERJOHN, THUMPLASSERIL V.ADEDEJI, JIDEECKERT, MARKUS A.
Owner HISERODT RICHARD DWYER