Process for preparing an alpha-lipoic acid/cyclodextrin complex and product prepared
a technology of cyclodextrin and alpha-lipoic acid, which is applied in the field of process for preparing an alpha-lipoic acid/cyclodextrin complex and product preparation, can solve the problems of large amount of water needed to solubilize cyclodextrin, yellow powder and unstable light, and poor solubility in water, so as to reduce the cost of the production process in a rapid and simple manner
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example 1
Preparation of a Cyclodextrin Alpha-Lipoic Acid Alpha Cyclodextrin Complex
[0025] 117.2 g of a 45% potassium hydroxide solution (0.940 mol) was added to 5.0 kg water and mixed at room temperature until clear. 194.0 g alpha-lipoic acid (99%, 0.931 moles) was added to the potassium hydroxide solution and mixed until clear. 1,046.0 g alpha cyclodextrin (9.25% water content, 0.977 moles) was added and stirred 3 hours until slightly cloudy to clear (in case of the amorphous silica as flowing agent the solution will be slightly cloudy). 0.940 mol of 12 N hydrochloric acid was slowly added until the pH reached pH 3 to precipitate the complex. The final aqueous mixture is spray dried immediately at 180° C.
example 2
Preparation of an Alpha-Lipoic Acid / Alpha Cyclodextrin Complex
[0026] 186.7 g of a 45% potassium hydroxide solution (1.498 moles) was added to 3910 g water and mixed at room temperature until clear. 300 g alpha-lipoic acid (99%, 1.439 moles) was added to the potassium hydroxide solution and mixed until clear clear (in case of the presence of amorphous silica as flowing agent the solution will be slightly cloudy). 1,572 g alpha cyclodextrin (at 9.25% water 1.468 moles) was added and stirred for 3 hours at room temperature until no further clarification was seen. 1.498 moles of 37% hydrochloric acid was added to precipitate the complex. With a minimal molar excess of hydrochloric acid in comparison to the potassium hydroxide used, the final pH of the solution was at pH 3. The final aqueous mixture was spray dried immediately at 180° C.
example 3
Preparation of an Alpha-Lipoic Acid / Alpha Cyclodextrin Complex
[0027] 1.44 moles of potassium hydroxide were added to 5.5 kg of water and mixed at room temperature until clear. The pH of this solution was at pH 14. 300 g alpha-lipoic acid (98%, 1.425 moles) was added to the potassium hydroxide solution and mixed until clear (in case of the presence of amorphous silica as flowing agent the solution will be slightly cloudy). 1.553 kg of dry alpha cyclodextrin (1.598 moles) was added and stirred 50 minutes at room temperature. 1.44 moles of 37% hydrochloric acid was added precipitating the complex. This mixture was stirred 30 minutes at room temperature. The final pH was at about pH 3. This aqueous mixture was spray dried immediately at about 180° C. inlet and about 80° C. outlet temperature.
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