Compounds, compositions and methods for the treatment of inflammatory diseases

a technology of compound composition and inflammatory disease, applied in the field of compound composition and method for the treatment of inflammatory diseases, can solve the problems of tissue injury, organ failure, inflammation in various organs of the body, etc., and achieve the effect of preventing oxidative stress-induced cell death
US20070208087A1Inactive Publication Date: 2007-09-06PROTEOTECH
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
PROTEOTECH
Publication Date
2007-09-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The use of a composition comprising a compound: where R is a C1-C10 alkylene group, in which, when the number of carbon atoms is at least 2, there are optionally 1 or 2 non-adjacent double bonds; 1 to 3 non-adjacent methylene groups are optionally replaced by NR1 (where R1 is H, alkyl, or acyl), O, or S; and 1 or 2 methylene groups are optionally replaced by a carbonyl or hydroxymethylene group for the preparation of a medicament or a pharmaceutical for the treatment of inflammatory diseases.
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Description

[0001] This application is a Continuation-in-Part of U.S. application Ser. No. 11 / 503,400 filed Aug. 10, 2006, now abandoned, which claimed priority to U.S. Provisional Application No. 60 / 707,567 filed Aug. 10, 2005. This application is also a Continuation-in-Part of U.S. application Ser. No. 10 / 077,596 filed Feb. 15, 2002, which is a Continuation-in-Part of application Ser. No. 10 / 053,625, now issued as U.S. Pat. No. 6,929,808 on Aug. 16, 2005.TECHNICAL FIELD

[0002] This invention relates to bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of inflammatory diseases such as arthritis, and in the manufacture of medicaments for such treatment. BACKGROUND OF THE INVENTION

[0003] Various forms of inflammation are characterized by activation of macrophages. Macrophages are thought to induce and maintain inflammatory processes mainly by ...

Claims

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