Method for the Treatment of Mammalian Skin Tissues Via Pulse Irradiation in the Presence of a Photoactive Compound

Inactive Publication Date: 2007-10-04
CLINIQUE DR DANIEL BAROLET
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0022] Advantageously, the claimed invention is relatively easy to perform and relatively safe. The claimed invention is fu

Problems solved by technology

However downtime must still be anticipated, such as redness, crust or more severe side effects that demands longer recovery time.
However, some powerful topical agents can irritate the skin.
For example, tretinoin used in potent anti-wrinkling regimens and

Method used

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  • Method for the Treatment of Mammalian Skin Tissues Via Pulse Irradiation in the Presence of a Photoactive Compound
  • Method for the Treatment of Mammalian Skin Tissues Via Pulse Irradiation in the Presence of a Photoactive Compound
  • Method for the Treatment of Mammalian Skin Tissues Via Pulse Irradiation in the Presence of a Photoactive Compound

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Experimental program
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Effect test

examples

In vitro Experiments:

In vitro Experiments: Human Reconstructed Skin Model

[0083] Cell culture media. Keratinocytes were grown in complete DME-HAM medium: a combination of Dulbecco-Vogt modification of Eagle's medium (DME) with Ham's F12 in a 3:1 proportion (Gibco), supplemented with 5% Fetal Clone II serum (FCSII) (HyClone, Logan, United States), 10 ng / mL epidermal growth factor (Austral biologicals, San Ramon, United States), 24.3 μg / mL adenin (Sigma), 5 μg / mL insulin (Sigma), 5 μg / mL transferrin (Roche), 2×10−9 M 3,3′5′ triiodo-L-thyronin (Sigma), 0.4 μg / mL hydrocortisone (Calbiochem, La Jolla, United States), 100 IU / mL penicillin G (Sigma), and 25 μg / mL gentamycin (Schering, Pointe-Claire, Canada). Fibroblasts were cultured in DME containing 10% fetal calf serum (FCS) (HyClone), 100 IU / mL penicillin G, and 25 μg / mL gentamycin.

[0084] Cell isolation. Human epidermal keratinocytes and dermal fibroblasts were isolated from normal skin specimens; keratinocytes are mainly found in ...

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Abstract

A method of treating mammalian skin tissues for causing a predetermined physiological change in the mammalian skin tissues. A treatment composition of matter is applied onto the mammalian skin. The mammalian skin is irradiated with a first pulse having a power density above an activation threshold power density and with a second pulse. The first pulse is emitted for a duration of from about 1 fem-tosecond to about 1 hour, and the first pulse is separated from the second pulse by an inter-pulse interval of from about 1 microsecond to about 10 seconds. The treatment composition of matter includes a photoreactive substance and is applied in an amount sufficient to cause physiological changes within the mammalian skin tissue upon the mammalian skin tissue being irradiated.

Description

This Application claims priority from U.S. Provisional Patent Application Ser. No. 60 / 601,117 filed Aug. 13, 2004.FIELD OF THE INVENTION [0001] The present invention relates to the field of treatment of living tissue such as the dermatological treatment of skin, and is particularly concerned with a method for the treatment of mammalian skin tissues. BACKGROUND OF THE INVENTION [0002] The first law of photochemistry states that light has got to be absorbed before photochemistry can occur, which stresses the importance of cellular absorption (Smith, 1981). Typically, photobiological effects are both wavelength and dose-dependent, and result from chemical and / or physical changes induced by non-ionizing radiation (Anderson and Parrish, 1981). When used at a proper wavelength, light activation of enzymes and other tissue components leads to changes in metabolism and induces metabolic modulations. [0003] As light energy is absorbed within the skin, light can be used to achieve desired cli...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/375A61N5/06A61P17/00A61K38/00
CPCA61K31/375A61N2005/0651A61N2005/007A61N2005/0652A61N5/062A61K41/00A61P17/00
Inventor BAROLET, DANIELBOUCHER, ANNIE
Owner CLINIQUE DR DANIEL BAROLET
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