Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Method for the Treatment of Mammalian Skin Tissues Via Pulse Irradiation in the Presence of a Photoactive Compound

Inactive Publication Date: 2007-10-04
CLINIQUE DR DANIEL BAROLET
View PDF7 Cites 30 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0022] Advantageously, the claimed invention is relatively easy to perform and relatively safe. The claimed invention is furthermore relatively painless when performed in vivo and gives clinically significant results in relatively few treatments.

Problems solved by technology

However downtime must still be anticipated, such as redness, crust or more severe side effects that demands longer recovery time.
However, some powerful topical agents can irritate the skin.
For example, tretinoin used in potent anti-wrinkling regimens and proven to stimulate collagen production in the dermis but may cause erythema, reducing compliance to the treatment.
Moreover, light-based techniques used to enhance skin appearance typically target dermal fibroblasts but have little effect on the epidermis.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for the Treatment of Mammalian Skin Tissues Via Pulse Irradiation in the Presence of a Photoactive Compound
  • Method for the Treatment of Mammalian Skin Tissues Via Pulse Irradiation in the Presence of a Photoactive Compound
  • Method for the Treatment of Mammalian Skin Tissues Via Pulse Irradiation in the Presence of a Photoactive Compound

Examples

Experimental program
Comparison scheme
Effect test

examples

In vitro Experiments:

In vitro Experiments: Human Reconstructed Skin Model

[0083] Cell culture media. Keratinocytes were grown in complete DME-HAM medium: a combination of Dulbecco-Vogt modification of Eagle's medium (DME) with Ham's F12 in a 3:1 proportion (Gibco), supplemented with 5% Fetal Clone II serum (FCSII) (HyClone, Logan, United States), 10 ng / mL epidermal growth factor (Austral biologicals, San Ramon, United States), 24.3 μg / mL adenin (Sigma), 5 μg / mL insulin (Sigma), 5 μg / mL transferrin (Roche), 2×10−9 M 3,3′5′ triiodo-L-thyronin (Sigma), 0.4 μg / mL hydrocortisone (Calbiochem, La Jolla, United States), 100 IU / mL penicillin G (Sigma), and 25 μg / mL gentamycin (Schering, Pointe-Claire, Canada). Fibroblasts were cultured in DME containing 10% fetal calf serum (FCS) (HyClone), 100 IU / mL penicillin G, and 25 μg / mL gentamycin.

[0084] Cell isolation. Human epidermal keratinocytes and dermal fibroblasts were isolated from normal skin specimens; keratinocytes are mainly found in ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Timeaaaaaaaaaa
Timeaaaaaaaaaa
Timeaaaaaaaaaa
Login to View More

Abstract

A method of treating mammalian skin tissues for causing a predetermined physiological change in the mammalian skin tissues. A treatment composition of matter is applied onto the mammalian skin. The mammalian skin is irradiated with a first pulse having a power density above an activation threshold power density and with a second pulse. The first pulse is emitted for a duration of from about 1 fem-tosecond to about 1 hour, and the first pulse is separated from the second pulse by an inter-pulse interval of from about 1 microsecond to about 10 seconds. The treatment composition of matter includes a photoreactive substance and is applied in an amount sufficient to cause physiological changes within the mammalian skin tissue upon the mammalian skin tissue being irradiated.

Description

This Application claims priority from U.S. Provisional Patent Application Ser. No. 60 / 601,117 filed Aug. 13, 2004.FIELD OF THE INVENTION [0001] The present invention relates to the field of treatment of living tissue such as the dermatological treatment of skin, and is particularly concerned with a method for the treatment of mammalian skin tissues. BACKGROUND OF THE INVENTION [0002] The first law of photochemistry states that light has got to be absorbed before photochemistry can occur, which stresses the importance of cellular absorption (Smith, 1981). Typically, photobiological effects are both wavelength and dose-dependent, and result from chemical and / or physical changes induced by non-ionizing radiation (Anderson and Parrish, 1981). When used at a proper wavelength, light activation of enzymes and other tissue components leads to changes in metabolism and induces metabolic modulations. [0003] As light energy is absorbed within the skin, light can be used to achieve desired cli...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K41/00A61K31/375A61N5/06A61P17/00A61K38/00
CPCA61K31/375A61N2005/0651A61N2005/007A61N2005/0652A61N5/062A61K41/00A61P17/00
Inventor BAROLET, DANIELBOUCHER, ANNIE
Owner CLINIQUE DR DANIEL BAROLET
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com