Anti-inflammatory properties of marine lipid compositions

a technology of marine lipids and compositions, applied in the field of marine lipid compositions, can solve the problems of low absorption ra

Inactive Publication Date: 2008-02-21
AKER BIOMARINE ASA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010] In some embodiments, the present invention provides methods for reducing symptoms of cognitive dysfunction in a child comprising administering an effective amount of a marine phospholipid composition, wherein said symptoms are selected from the group consisting of ability to complete task, ability to stay on task, ability to follow instructions, ability to complete assignments, psychomotor function, long term memory, short term memory, ability to make a decision, ability to follow through on decision, ability to self-sustain attention, ability to engage in conversations, sensitivity to surroundings, ability to plan, ability to carry out plan, ability to listen, interruptions in social situations, temper tantrums, level / frequency of frustration, level / frequency restlessness, frequency / level fidgeting, ability to exhibit delayed gratification, aggressiveness, demanding behavior / frequency of demanding behavior, sleep patterns, restive sleep, interrupted sleep, awakening behavior, disruptive behavior, ability to exhibit control in social situations, ability to extrapolate information and ability to integrate information. In some embodiments, the child exhibits one or more symptoms of Attention Deficit Hyperactivity Disorder (ADHD), is suspected of having ADHD, or has been diagnosed with ADHD. In some embodiments, the child exhibits one or more symptoms of autistic spectrum disorder, is suspected of having autistic spectrum disorder, or has been diagnosed with autistic spectrum disorder. In further embodiments, the present invention provides methods of increasing cognitive performance in an aging mammal comprising administering an effective amount of a marine phospholipid composition. In some embodiments, the cognitive performance is selected from the group consisting of memory loss, forgetfulness, short-term memory loss, aphasia, disorientation, disinhibition, and behavioral changes. In some embodiments, the mammal is a human. In some embodiments, the mammal is a pet selected from the group consisting of cats and dogs. In some embodiments, the mammal has symptoms of age-associated memory impairment or decline.

Problems solved by technology

However, for certain conditions i.e. pathological conditions such as extrahepatic cholestasis and for pre-term infants the absorption can be low.

Method used

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  • Anti-inflammatory properties of marine lipid compositions
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  • Anti-inflammatory properties of marine lipid compositions

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0057] The difference in bioavailability and bioefficacy between the marine lipid composition of the present invention and a fish oil were investigated in a rat experiment. The rat feed was prepared using AIN-93 except that soybean oil was removed from the feed. The pelleted AIN-93 diet was ground and the marine lipid compositions (PL 1 and PL 2) as well as fish oil (TG oil) and control were added to this ground feed. The marine lipid compositions were prepared using enzymatic (lipase) catalyzed transesterification of soy lecithin with fish oil fatty acids according to the method described in Example 4, followed by the addition of a triglyceride carrier and short path distillation. The concentration of EPA, DHA and 18:3 n-3 in the different diets can be seen in the table below (table 1).

TABLE 1Amount of different fatty acid in the final feed productsg / 100 gg / 100 gg / 100 gSUM g / 100 gEPADHA18:3n3EPA + DHA + 18:3n3ControlT4000.260.26TG OilT10.610.390.241.23PL 1T20.610.350.261.22PL 2T3...

example 2

[0059] The total fatty acid profile for the lipids in the brains (table 2), adipose tissue (table 3), liver (table 4), testicles (table 5) and heart (table 6) were isolated from the rats in example 1. The PL 1 composition increases the DHA content in brain and adipose tissue more than the TG composition. The PL 1 composition increase the EPA content in the adipose tissue more than the TG composition. It is to be observed that the PL1 composition increases the EPA / DHA content in the phospholipids and in the total lipids of the different tissues as well as reduces the AA / EPA ratio more than the TG oil composition.

TABLE 2Fatty acid profile of the total lipids isolated from the rat brain (mmol / g lipids).18:118:218:3 n320:3ARAEPA22:422:5 n622:5 n3DHATG-oil370120.355.7153.72.268.55.65.0191.4PL-1399120.337.2160.72.270.27.25.7203.3PL-2345130.335.7141.61.760.85.83.4190.3Control363120.305.2174.90.181.47.61.7189.6

[0060]

TABLE 3Fatty acid profile of the total lipids isolated from adipose tissu...

example 3

[0064] The fatty acid profile of the phospholipids isolated from the brain (table 7), adipose tissue (table 8), liver (table 9), testicles (table 10) and heart (Table 11) in the rats from example 1 were determined.

TABLE 7Fatty acid profile of the phospholipids isolated from the brain (mmol / g lipids).18:118:218:3 n320:3ARAEPA22:422:5 n622:5 n3DHATG-oil260.89.90.24.5147.171.972.85.65.3196.8PL-1289.910.90.14.2115.071.454.74.34.5170.1PL-2232.62.10.64.2122.381.257.44.40.7175.9Control288.84.43.5181.600.186.87.30.5213.1

[0065]

TABLE 8Fatty acid profile of the phospholipids isolated fromthe adipose tissue (mmol / g lipids).18:118:218:3 n320:3ARAEPA22:422:5 n622:5 n3DHATG-oil0.70.90.040.040.450.100.00.00.00.17PL-10.60.50.040.020.240.060.00.00.00.09PL-20.50.60.030.040.370.050.00.00.00.13Control0.50.40.040.030.570.010.00.00.00.04

[0066]

TABLE 9Fatty acid profile of the phospholipids isolated from the liver (mmol / g lipids).18:118:218:3 n320:3ARAEPA22:422:5 n622:5 n3DHATG-oil84.2165.44.411.5256.961....

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Abstract

Novel marine lipid compositions comprising triglycerides and omega-3 rich phospholipids are described. The compositions are characterized by providing highly bioavailable omega-3, increased tissue incorporation of omega-3 and reduced concentration of pro-inflammatory cytokines.

Description

[0001] This application claims the benefit of U.S. Provisional Applications 60 / 798,026, 60 / 798,027, and 60 / 798,030, all filed May 5, 2006, and U.S. Provisional Application 60 / 872,096, filed Dec. 1, 2006, each of which is incorporated herein by reference in their entirety.FIELD OF THE INVENTION [0002] The present invention relates to novel marine lipid compositions comprising combinations of omega-3 fatty acid rich functional phospholipids and omega-3 fatty acid rich triglycerides. In addition, food supplements, functional food, drugs and feed products comprising such compositions are provided along with methods of their use. BACKGROUND OF THE INVENTION [0003] Marine lipids such as omega-3 rich triglycerides and omega-3 rich phospholipids can be isolated from a number of different natural sources such as fish, crustaceans, plankton, seals, whales as well as algae using extraction technologies. In addition, they can be prepared industrially using chemical or bio-catalytical methods su...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/12A61K31/685A61P29/00C07F9/02
CPCC07F9/10A61K31/685A61P29/00A61P3/02
Inventor BRUHEIM, INGEGRIINARI, MIKKOBANNI, SEBASTIANOSAEBO, PER CHRISTIANFUGLSETH, ERIK
Owner AKER BIOMARINE ASA
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