Microfluidic radiosynthesis of a radiolabeled compound using electrochemical trapping and release

a radiosynthesis and microfluidic technology, applied in the field of microfluidic devices, can solve the problems of prolonging the life of the device, achieve the effects of improving the operation speed of the device, reducing the cost of the device, and high radiochemical labeling yield

Inactive Publication Date: 2009-04-16
CAL TECH +1
View PDF10 Cites 22 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]The present invention relates generally to microfluidic devices and related technologies. More specifically, embodiments of the present invention relate to trapping and release of radioactive isotopes inside a microreactor, a vial, a channel, or similar device, thus eliminating the need for azeotropic drying and several dead-end filling steps, as well as the necessity to move concentrated radioisotopes from one compartment of the device to another. In accordance with example embodiments of the present invention, radioisotope enrichment is carried out internally within a radiochemical synthesis chip, allowing faster and more robust operation. The disclosed methods and apparatus do not require an ion exchange column to trap the radioisotope, produce high radiochemical labeling yields, while providing significant increase in the device operational speed and reducing material stress

Problems solved by technology

The disclosed methods and apparatus do not require an ion exchange column to trap the radioisotope, produce high radiochemical labeling yield

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Microfluidic radiosynthesis of a radiolabeled compound using electrochemical trapping and release
  • Microfluidic radiosynthesis of a radiolabeled compound using electrochemical trapping and release
  • Microfluidic radiosynthesis of a radiolabeled compound using electrochemical trapping and release

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031]In the following description, for purposes of explanation and not limitation, details and descriptions are set forth in order to provide a thorough understanding of the present invention. However, it will be apparent to those skilled in the art that the present invention may be practiced in other embodiments that depart from these details and descriptions.

[0032]A “microfluidic device” or “microfluidic chip” or “synthesis chip” or “chip” is a unit or device that permits the manipulation and transfer of small amounts of liquid (e.g., microliters or nanoliters) into a substrate comprising micro-channels and micro-compartments. The device may be configured to allow the manipulation of liquids, including reagents and solvents, to be transferred or conveyed within the micro channels and reaction chamber using mechanical or non-mechanical pumps. The device may be constructed using micro-electromechanical fabrication methods as known in the art. Alternatively, the devices can be machi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Login to view more

Abstract

Methods and apparatus enable radiosynthesis of radiolabeled compounds using electrochemical trapping and release. The trapping and release of radioactive isotopes all occur inside a microreactor, a vial or similar device, thus eliminating the need for azeotropic drying and several dead-end filling steps, as well as the necessity to move concentrated radioisotopes from one compartment of the chip to another. These and other features allow radioisotope enrichment to be carried out internally within a radiochemical synthesis chip, providing faster and more robust operation, as well as producing very high radiochemical labeling yields.

Description

RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Application No. 60 / 950,976 filed Jul. 20, 2007, the contents of which is hereby incorporated in its entirety by reference.FIELD OF THE INVENTION[0002]The present invention relates generally to microfluidic devices and related technologies. More specifically, the invention relates to methods and devices for microfluidic radiosynthesis of radiolabeled compounds.BACKGROUND OF THE INVENTION[0003]This section is intended to provide a background or context to the invention that is recited in the claims. The description herein may include concepts that could be pursued, but are not necessarily ones that have been previously conceived or pursued. Therefore, unless otherwise indicated herein, what is described in this section is not prior art to the description and claims in this application and is not admitted to be prior art by inclusion in this section.[0004]Microfluidic devices have been used for the preparati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C25B3/08C25B3/28
CPCC07B59/00
Inventor ELIZAROV, ARKADIJ M.KOLB, HARTMUTH C.VAN DAM, R. MICHAELHEATH, JAMES R.EDGECOMBE, BRIANMOTAMEDI, FARSHADSTEPHEN, ANTHONYGIARDELLO, MICHAEL A.
Owner CAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap