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Composition for preventing and treating fatty liver

a technology for fatty liver and composition, applied in the direction of antinoxious agents, peptide/protein ingredients, metabolic disorders, etc., can solve the problems hepatic triglyceride accumulation, serious public health problems, etc., to prevent and treat fatty liver disease, reduce the risk factors of fatty liver disease, and improve liver function

Inactive Publication Date: 2010-01-07
NATIONAL CHUNG HSING UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]The object of the present invention is to provide a composition for effectively reducing risk factors of fatty liver disease, improving liver function, and preventing and treating fatty liver disease.
[0016]In the composition of the present invention, the lactoferrin is a glycoprotein that is capable of combining with metal ions. Each lactoferrin molecule can be combined with two trivalent chromium ions and form a trivalent chromium lactoferrin complex. In comparison to the low absorption rate of inorganic chromium and organic chromium (the absorption rate of inorganic chromium only ranges from 0.4% to 3%), the trivalent chromium-lactoferrin complex in the composition of the present invention can be more efficiently absorbed and utilized by the human body.
[0017]Therefore, the composition of the present invention can be taken by the high-risk population and patients for fatty live disease. Taking the composition of trivalent chromium and lactoferrin in the present invention, not only can replenish the organic chromium efficiently, but also can reduce the risk factors of fatty liver disease, such as obesity, hyperglycemia, hyperlipidemia, insulin resistance, and oxidantive stress, and then enhance the normal metabolism of fat, carbohydrates, and protein. Therefore, taking the composition of trivalent chromium and lactoferrin in the present invention can effectively prevent and treat fatty liver.

Problems solved by technology

Moreover, fatty liver disease may progress to advanced fibrosis, cirrhosis and hepatocellular carcinoma and might lead to serious public health problems.
However, the metabolic abnormalities may impair hepatic lipid export, lead to hepatic triglyceride accumulation, and induce the fatty liver disease.
However, the therapeutic effect of these drugs on the fatty liver is limited.
To date, there is no proven effective therapies available for the prevention and control of fatty liver disease.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024]Lactoferrin powder (3 g) and chromium (III) chloride hexahydrate (0.5 g) are added to pure water (1 liter), followed by stirring to form a solution. The solution is well-mixed, spray-dried, and then mixed with buttermilk powder (196 g) and whey protein (100 g) to form the composition containing trivalent chromium lactoferrin of the present invention.

example 2

[0025]Lactoferrin powder (60 g), whey protein (400 g) and chromium (III) chloride hexahydrate (1 g) are added to pure water (2 liter) and heated to around 50° C., followed by stirring to form a solution. The solution is mixed with buttermilk powder (200 kg) and spray-dried to form the composition containing trivalent chromium lactoferrin of the present invention.

example 3

[0026]Lactoferrin powder (3 g), whey protein (30 g) and chromium (III) chloride hexahydrate (154.5 g) are added to pure water (1 liter) and heated to around 50° C., followed by stirring to form a solution. The solution is mixed with buttermilk powder (50 kg) and whey protein (25 kg) and spray-dried to form the composition containing trivalent chromium lactoferrin of the present invention.

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Abstract

A composition for preventing and treating fatty liver is disclosed. The composition includes a lactoferrin and a trivalent chromium compound. The trivalent chromium compound of the present invention is selected from the group consisting of chromium (III) chloride hexahydrate, chromium (III) chloride, chromium (III) acetate, chromium (III) sulfate, chromium picolinate, chromium nicotinate, chromium GTF, chromium yeast extract, other inorganic salts of trivalent chromium, other organic salts of trivalent chromium, and combinations thereof. The composition of the present invention can provide a beneficial effect in preventing and treating fatty liver by effectively reducing multiple risk factors of fatty liver disease.

Description

BACKGROUND OF THE INVENTION[0001]1. Field of the Invention[0002]The present invention relates to a composition for preventing and treating fatty liver and, more particularly, to a composition containing trivalent chromium lactoferrin, which can prevent and treat fatty liver.[0003]2. Description of Related Art[0004]Owing to the development in economics, populations suffered from fatty liver disease have gradually increased. Fatty liver disease is now recognized as the most common liver disease in the world. Moreover, fatty liver disease may progress to advanced fibrosis, cirrhosis and hepatocellular carcinoma and might lead to serious public health problems. Therefore, it is really important for the modern people to study how to prevent and control the fatty liver.[0005]The liver plays a central role in lipid metabolism, importing serum free fatty acids and manufacturing, storing and exporting lipids and lipoproteins. However, the metabolic abnormalities may impair hepatic lipid expo...

Claims

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Application Information

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IPC IPC(8): A61K38/40A61K33/24
CPCA23L1/304A23L1/3056A61K33/24A61K35/20A61K36/06A61K38/40A61K2300/00A23L33/16A23L33/19A61P1/16A61P3/06
Inventor MAO, FRANK CHIAHUNGCHEN, WEN-YING
Owner NATIONAL CHUNG HSING UNIVERSITY
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