Interleukin-1 receptor antagonists, compositions, and methods of treatment

a technology of interleukin-1 and receptor, applied in the field of il1 receptor antagonists, can solve the problems of toxicity and secondary effects, limited treatment options for il-1-associated pathologies, and harmful actions of il-1
US20100041609A1Inactive Publication Date: 2010-02-18VALORISATION RECH SOC & COMMANDITE
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
VALORISATION RECH SOC & COMMANDITE
Publication Date
2010-02-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

Peptides that are designed to inhibit the biological activity of the IL-1R type 1 receptor and inhibit IL-1R / IL-1RacP related cell signaling and biological activity are disclosed. Compositions comprising IL-1R antagonists of the present invention are useful in the treatment of IL-1 related diseases or conditions such as arthritis, rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease as well as other chronic or acute inflammatory diseases. This invention also discloses an isolated compound having an IL-1R antagonist activity, said compound being selected from the group consisting of: a peptide comprising the amino acid sequence RYTPELX, wherein R, Y, T, P, E, L, refer to their corresponding amino acids, and X is selected from no amino acid and alanine (A); and a derivative of (a) wherein the derivative incorporates one, two or three amino acid modification selected from an amino acid addition, deletion or substitution in the RYTPEL portion of the peptide, and wherein said derivative maintains its antagonist IL-1R activity.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to IL-1 receptor antagonists and methods of modulating IL-1 receptors activity with same. More specifically, the present invention is concerned with extracellular, non-competitive IL-1 receptor (IL1R / IL1RAcP) peptides and peptidomimetic antagonists, their identification and their therapeutic uses. More particularly, the present invention relates to peptide and peptidomimetic antagonists for use in the treatment of IL-1 associated diseases such as rheumatoid arthritis and inflammatory bowel disease. The present invention has application in the field of biochemistry and medicinal chemistry.BACKGROUND OF THE INVENTION

[0002] Cytokines are generic terms for designating biologically active hormone-like proteins (interleukins, interferons, tumor necrosis factor, growth factors) that mediate their effects through a superfamily of receptors. Cytokines and their receptors constitute a powerful control network by which cells signal and c...

Claims

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