Treatment Method

Inactive Publication Date: 2011-01-13
DEC INT NZ LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0137]In one embodiment the final treatment composition may also include at least one component which is capable of controlling the time release of the composition. This may be used to effectively treat mastitis over an extended period of time. Known components which could be used for this purpose would be well known to one skilled in the art.
[0138]In a preferred em

Problems solved by technology

The range of different organisms that can cause mastitis and their varying susceptibilities to antibiotics presents the greatest challenge in the treatment and prevention of mastitis in dairy cows.
There is an increased risk of intra-mammary infection during the dry period because the teat is no longer protected by the flow of milk through the teat.
The large volume of milk may also overwhelm the natural defense systems in the udder.
Teat seal formulations are currently available—however it is not known for these to include milk components, such as lactoferrin or lactoperoxidase.
Antibiotics require withholding periods which can increase the time and effort required by the farmer, and may not effectively target the pathogens causing the mastitis.
Aminoglycosides have a broader spectrum of activity but are not effective against bacteria wi

Method used

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Embodiment Construction

[0227]FIG. 1 shows the elution profile of the cationic fraction from cation exchange. This represents all the protein peaks (as detected at 280 nm) that would be present in a single fraction eluted in a gradient from 80-100 mS. The main components in the cationic fraction are immunoglogulin, lactoperoxidase, lactoferrin, and a group of minor components that include angiogenin.

[0228]FIG. 2 shows the main fractions separated on SDS-PAGE, and indicates the band that was excised for Mass Spectroscopy and identified as bovine angiogenin.

[0229]The immunoglobulin fraction shows PIGR (76 kDa) as the predominant band, and the heavy (52 kDa) and light chains of immunoglobulin.

[0230]The Lp fraction is mainly lactoperoxidase with a small amounts of heavy and light chains of immunoglobulin and angiogenin.

[0231]The intermediate fraction has a prominent band of lactoperoxidase and lactoferrin (80 kDa) and a band at around 15 kDa that was identified by Mass Spectrometry as angiogenin, a band at app...

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Abstract

A treatment composition for treating or preventing bovine mastitis, the treatment composition characterised in that it includes at least two components which have an isoelectric point of or above substantially 6.8 and is extracted from milk, or a milk derived substance.

Description

TECHNICAL FIELD[0001]This invention relates to a treatment method.[0002]In particular it relates to a method of treating bovine mastitis, and a method of producing the treatment composition.BACKGROUND ART[0003]Mastitis is an inflammatory disease of the mammary gland of a mammal.[0004]The inflammation is the result of infection by any of a multitude of bacteria, mycoplasmas, yeast and fungi. The range of different organisms that can cause mastitis and their varying susceptibilities to antibiotics presents the greatest challenge in the treatment and prevention of mastitis in dairy cows.[0005]Bovine mastitis may be caused by Gram negative bacteria such as Escherichia coli, Klebsiella species and Enterbacter species, or by Gram-positive bacteria such as Staphylococcus aureus, Enterococci species, and Streptococci such as Streptococcus uberus, Streptococcus agalactiae and Streptococcus dysgalactiae, and by Mycoplasma bovis. [0006]Bacterial infection via the teats is the most common cause...

Claims

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Application Information

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IPC IPC(8): A61K39/00A61K35/20A61K38/44A61K38/47A61P31/04A61P31/00
CPCA61K35/20A61K38/54A61K38/44A61K45/06A61K38/40A61K38/30A61K38/19A61K38/1841A61K38/1732C12Y111/01007A61K38/1891A61K2300/00A61P31/00A61P31/04Y02A50/30
Inventor BRAGGER, JUDITH MARY
Owner DEC INT NZ LTD
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