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Wound cleansing apparatus in-situ

a wound cleansing and in-situ technology, applied in the field of wound cleansing apparatus, can solve the problem that relevant devices tend to be not portable, and achieve the effect of promoting wound healing

Active Publication Date: 2011-04-14
SMITH & NEPHEW PLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0011] It would be desirable to provide a system of therapy that can remove materials deleterious to wound healing from wound exudate, without substantially diluting materials that are beneficial in promoting wound healing in contact with the wound bed, and which can continuously supply and recirculate such materials to the wound simultaneously.

Problems solved by technology

Dialysis also requires large amounts either of bodily fluids, such as blood, or dialysate, and consequently the relevant devices tend not to be portable.

Method used

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  • Wound cleansing apparatus in-situ
  • Wound cleansing apparatus in-situ
  • Wound cleansing apparatus in-situ

Examples

Experimental program
Comparison scheme
Effect test

example 1

Cleansing Fe(II) from Aqueous Solution with the Apparatus of FIG. 1: Single-Phase Hand-Syringe Pumped Dressing Containing Solid Sequestrant (Cadexomer—Desferrioxamine)

[0386] A hand-syringe pumped dressing as shown in FIG. 14 was made up. The cleansing chamber (15) contains a solid particulate (not shown) desferrioxamine supported on Cadexomer (50 mg) to sequester and remove deleterious Fe(II) ions from surrogate exudate.

[0387] The porous film (12) and a permeable membrane (13), both made of Porvair permeable membrane, are chosen to allow perfusion and flow under syringe pumping through the cleanser but to contain the solid reagent.

[0388] In triplicate, the dressing as shown in FIG. 1 was applied to a 9.60 ml capacity circular wound cavity (cast in Perspex) containing an aqueous solution of ferrous chloride tetrahydrate (Aldrich) (9.60 ml, 200 μmolar).

[0389] The solution was repeatedly completely withdrawn and completely reinjected using the device syringe. At each withdrawal, a ...

example 2

Neutralising the pH of an Acidic Solution with the Apparatus of FIG. 15: Single-Phase Recirculating Pumped Dressing Containing Solid Acid Scavenger, ScavengePore® Phenethyl Morpholine

[0393] A recirculating pumped dressing as shown in FIG. 15 was made up. The cleansing chamber (15) contains a solid particulate (not shown) of ScavengePore® phenethyl morpholine (Aldrich) (50 mg), which is a low-swelling macroporous highly crosslinked polystyrene / divinylbenzene ion-exchanger resin matrix, with 200-400 micron particle size, to scavenge and remove protons, which are acidic species which adversely affect the pH in the wound exudate, from surrogate exudate.

[0394] The porous film (12) and a permeable membrane (13), both made of Porvair permeable membrane, are chosen to allow perfusion and flow under pumping through the cleanser but to contain the ion-exchange reagent.

[0395] In triplicate, 4.80 ml DMEM was In triplicate, Device 2 was applied to a 9.60 ml capacity circular wound cavity (cas...

example 3

Cleansing Elastase from Aqueous Solution by Diffusion Across a Dialysis Membrane with the Apparatus of FIG. 12: Two-Phase Recirculating Pumped Dressing Containing No Reagent

[0398] A recirculating pumped dressing as shown in FIG. 12 was made up. The cleansing chamber (5) is in the form of tubules made from a polymer membrane that is selectively permeable to a deleterious materials in wound exudate (elastase). These in an array under the backing layer (3) within the wound space between a first boss (71) and a second boss (72) both mounted in the backing layer (3). The tubules contain a dialysate fluid and are in a circuit with a pump (7).

[0399] In triplicate, the dressing as shown in FIG. 12 was applied to a 9.60 ml capacity circular wound cavity (cast in Perspex) containing elastase solution (porcine pancreatic elastase, Sigma) (4.80 ml, 0.5 mgml−1 in TRIS buffer, pH 8.2, 0.2 M). The remaining cavity volume was filled with glass beads. The inlet and outlet ports were connected to t...

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Abstract

An apparatus for cleansing wounds, in which wound exudate is removed from a wound bed and selectively cleansed and returned to the wound. The cleansing means removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The associated wound dressing and cleansing means are conformable to the wound, and may have irrigant fluid circulated from a reservoir by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation of U.S. patent application Ser. No. 10 / 575,871, published as US 2007 / 0167926 and filed on Jan. 29, 2007, which is a U.S. National Phase of the PCT International Application No. PCT / GB04 / 04549, filed on Oct. 28, 2004, which claims priority to application GB 0325129.5, filed on Oct. 28, 2003.FIELD OF THE INVENTION [0002] The present invention relates to apparatus and a medical wound dressing for cleansing wounds, and a method of treating wounds using such apparatus. [0003] It relates in particular to such an apparatus, wound dressing and method that can be easily applied to a wide variety of, but in particular chronic, wounds, to cleanse them of materials that are deleterious to wound healing, whilst retaining materials that are beneficial in particular to wound healing. BACKGROUND OF THE INVENTION [0004] Before the present invention, aspirating and / or irrigating apparatus were known, and tended to be us...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M1/00A61F13/00A61M3/02A61M27/00A61M35/00
CPCA61M1/0037Y10T29/49826A61M1/0062A61M1/0084A61M1/0088A61M3/0229A61M27/00A61M35/00A61M2205/075A61M2205/106A61M2205/7518A61M2205/8206A61F13/00068A61M1/0068A61M1/0072A61M1/009A61M1/0058A61M3/0216A61M3/022A61M35/30A61M1/75A61M1/81A61M1/82A61M1/962A61M1/85A61M1/92A61M1/915A61M1/772A61M1/916A61M1/77A61M1/985A61F13/0216A61F13/0259A61F2013/00357A61F13/0206A61F13/0213
Inventor BLOTT, PATRICKGREENER, BRYANHARTWELL, EDWARDLEE-WEBB, JULIANNICOLINI, DEREK
Owner SMITH & NEPHEW PLC
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