Novel compositions and methods

US20110117119A1Inactive Publication Date: 2011-05-19GLAXOSMITHKLINE BIOLOGICALS SA +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
GLAXOSMITHKLINE BIOLOGICALS SA
Publication Date
2011-05-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is directed to a polypeptide which comprises: (i) an Rv3616c protein sequence; (ii) a variant of an Rv3616c protein sequence; or (iii) an immunogenic fragment of an Rv3616c protein sequence for use in the treatment or prevention of latent TB. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of latent tuberculosis.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to polypeptides and polynucleotides for use in the treatment or prevention of tuberculosis, in particular for use in the treatment or prevention of latent tuberculosis and in the prevention or delay of reactivation of tuberculosis (and also to related methods). The present invention further relates to pharmaceutical and immunogenic compositions comprising said polypeptides and polynucleotides, and to methods for the diagnosis of tuberculosis (in particular latent tuberculosis).BACKGROUND OF THE INVENTION

[0002] Tuberculosis (TB) is a chronic infectious disease caused by infection with Mycobacterium tuberculosis and other Mycobacterium species. It is a major disease in developing countries, as well as an increasing problem in developed areas of the world. More than 2 billion people are believed to be infected with TB bacilli, with about 9.2 million new cases of TB and 1.7 million deaths each year. 10% of those infected with TB b...

Claims

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