Lyme disease vaccine

a technology for lyme disease and vaccine, applied in the field of lyme disease vaccine and diagnostic, can solve the problems of ineffective use of full-length ospa, high socio-economic cost of lyme disease, and inability to provide an efficacious vaccine for use in the prevention and/or treatment of lyme disease, etc., and achieve the effect of broad protection against infection
US20110262475A1Inactive Publication Date: 2011-10-27VIRGINIA COMMONWEALTH UNIV
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
VIRGINIA COMMONWEALTH UNIV
Publication Date
2011-10-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

Antigenic polypeptides comprising linear immunodominant epitopes of Borrelia outer surface protein A (OspA) or Borrelia outer surface protein C (OspC) are useful as vaccines against Lyme disease, and as diagnostics for detecting Borrelia infections. The OspA and OspC antigenic polypeptides typically comprise a plurality of peptides representing epitope containing regions from multiple distinct phyletic groups. The antigenic polypeptides may also include epitopes from both Borrelia OspA and Borrelia OspC.
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Description

BACKGROUND OF THE INVENTION

[0001] 1. Field of the Invention

[0002] The invention generally relates to a vaccine and diagnostic for Lyme disease. In particular, the invention provides a Lyme disease vaccine and diagnostic that includes linear Borrelia outer surface protein A (OspA) epitopes and / or Borrelia outer surface protein C (OspC) epitopes, usually from multiple distinct phyletic groups.

[0003] 2. Background of the Invention

[0004] Lyme disease is the most common arthropod-borne disease in North America and Europe, where in some areas up to 3% of the population is infected annually. Lyme disease is caused by the spirochetes Borrelia burgdorferi, B. garinii and B. afzelii. Transmission to mammals occurs through the bite of infected Ixodes ticks. Infection results in a multi-systemic inflammatory disease with early stage symptoms that may include erythema migrans, low-grade fever, arthralgia, myalgia, and headache. Late stage clinical manifestations can be severe and may include in part...

Claims

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