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Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same

a technology of complex carbohydrates and essential oils, applied in the direction of drug compositions, biocide, oil/fat/waxes non-active ingredients, etc., can solve the problems of not revealing or suggesting the use of hyaluronic acid in combination with essential oils, and limiting research activities to determine. , to achieve the effect of preventing or treating the effect, and reducing the risk of side effects

Inactive Publication Date: 2011-11-03
BROWN HAROLD G +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach effectively prevents and treats a broad spectrum of diseases and conditions, including arthritis, cancer, and heart disease, by blocking the cascades, providing rapid relief and long-lasting effects with minimal adverse reactions.

Problems solved by technology

At present, this oligosaccharide is so difficult to prepare / obtain that the cost is prohibitive and limits research activities to determine its mechanism of action.
Schultz et al. does not disclose or suggest the use of hyaluronic acid in combination with essential oils, use of other complex carbohydrate macromolecules, oral application or mucosal application.
However, it does not produce a reaction when applied to the skin or mucous membranes of mammals including humans, dogs, cats, horses, cattle, swine, rabbits, guinea pigs and mice.
These interactions are strong enough to cause the leukocytes to roll along the blood vessel walls to the site of trauma instead of flowing freely through such vessels, but not strong enough to cause these leukocytes to slow down.
Integrins, by themselves, do not bind well to epithelium.
Unstable plaques are “swarming with T cells and macrophages” causing inflammation and make these plaques unstable.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0072]High molecular weight (>750,000) cosmetic grade hyaluronic acid obtained from Meiji Seika Kaisha, Ltd, was dissolved in distilled / deionized water (DI) to a concentration of from 1.1 to 1.5% wt / vol. This solution was treated with high pH and high temperature to break down the molecular weight to 1000 c / s to <10 c / s as a result of this treatment. This hyaluronic acid was adjusted to 1.0% wt / vol by dilution in DI water. The 1.0% hyaluronic acid solution was aliquoted into 10 vials with 100 mL each. Various essential oils were added to each vial at a concentration of 2.0% vol / vol. The resulting suspensions were mixed at room temperature for 2-3 hours. The following essential oils were tested in this experiment: Rosemary Oil, Tea Tree Oil, Camphor Oil, Oil of Wintergreen, Eucalyptus Oil, Cinnamon Oil, Sage Oil, Jojoba Oil, Lemon Oil and Oil of Clove. All of the essential oils were obtained from Loranne Oils. All preparations were held at 4° C. for 14 days after which they were eval...

example 2

[0082]High molecular weight (>750,000) cosmetic grade hyaluronic acid was obtained from Meiji Sieka Kaisha, Ltd. It was dissolved in distilled / deionized water (DI) to a concentration of 1.0% wt / vol. The viscosity of this solution at 37° C. was >1000 c / s and the molecular weight was >750,000. The 1.0% hyaluronic acid solution was aliquoted into 10 vials with 100 mL each. Various essential oils were added to each vial at a concentration of 2.0% vol / vol. The resulting suspensions were mixed at room temperature for 2-3 hours. The following essential oils obtained from Loranne Oils were tested in this experiment: Rosemary Oil, Tea Tree Oil, Camphor Oil, Oil of Wintergreen, Eucalyptus Oil, Cinnamon Oil, Sage Oil, Jojoba Oil, Lemon Oil and Oil of Clove. All preparations were held at 4° C. for 7 days after which they were evaluated for their suspension characteristics and for sterility according to procedures described in EXAMPLE 1. All oils remained in suspension due to the viscosity of th...

example 3

[0089]A 1.0% wt / vol solution of dermatan sulfate (chondroitin sulfate B obtained from SIGMA Chemical Company) was prepared using DI water. The viscosity of this preparation was <10 c / s. The molecular weight was 15,000. This preparation was mixed 1:1 with the 1.0% wt / vol high molecular weight hyaluronic acid solution described in EXAMPLE 2. Five aliquots of 30 mL each were dispensed into vials. To the first aliquot was added 2.0% vol / vol Rosemary Oil. To vials 2-4 was added either Eucalyptus Oil, Wintergreen Oil or Tea Tree Oil (all obtained from Loranne Oils). No essential oils were added to the fifth vial. All preparations were held at 4° C. for 7 days after which they were evaluated for their suspension characteristics. All oils remained in suspension due to the viscosity of the hyaluronic acid. Each suspension was remixed and aliquoted into 10 mL amounts in 25 mL vials. Three patients with chronic pain / swelling complaints were given one vial of each preparation to evaluate. They ...

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Abstract

The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates with or without natural or synthetic essential oils can work effectively as a topical, oral or mucosal pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers and prevent and treat numerous other conditions and diseases. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion, metastatic and coronary cascades.

Description

[0001]This application is a Divisional Application of co-pending Application No. 09 / 890,425 filed on Feb. 19, 2002, which is the U.S. National Phase of PCT / US2000 / 002328, filed on Feb. 1, 2000, which claims priority under 35 USC 119(e) on Provisional applications U.S. Ser. Nos. 60 / 117,988, 60 / 127,749, 60 / 137,098, 60 / 142,306 and 60 / 166,326 filed on Feb. 1, 1999, Apr. 6, 1999, Jun. 2, 1999, Jul. 3, 1999 and Nov. 19, 1999, respectively. Each of the above applications are herein incorporated by reference.BACKGROUND AND FIELD OF THE INVENTION[0002]The invention relates to a method of preventing and treating diseases and conditions of mammals associated with the adhesion, metastatic and coronary cascades comprising applying a composition of complex carbohydrates and essential oils topically, orally or mucosally on a repeated basis. The invention also encompasses a method of preventing and treating diseases and conditions associated with the adhesion, metastatic and coronary cascades compr...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/715A61P35/00A61P35/04A61K31/702A61K9/00A61K31/726A61K31/727A61K31/728A61K31/736A61K31/737A61K47/44
CPCA61K9/0014A61K31/715A61K31/726A61K31/727A23L1/30A61K31/736A61K31/737A61K47/44A23K1/1643A61K31/728A23K20/163A23L33/10A61P35/00A61P35/04Y02A50/30
Inventor BROWN, HAROLD G.COOPER, CAROL A.HENNESSY, KRISTINA J.BROWN, KAREN K.
Owner BROWN HAROLD G