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Methods For Detection Of Gastric Cancer

a gastric cancer and gastric cancer technology, applied in the field of gastric cancer detection methods, can solve the problems of its cost effectiveness remaining an issue, and the discovery of biomarkers in body fluids is not without challenges, so as to improve the outcome of gastric cancer patients

Active Publication Date: 2012-02-02
NAT UNIV OF SINGAPORE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0004]Gastric cancer has one of the highest morbidities and mortalities worldwide. Early detection is a key measure to improve the outcome of gastric cancer patients

Problems solved by technology

Endoscopy is widely used for screening; however this methodology involves invasive procedure and its cost effectiveness remains an issue.
However biomarker discovery in body fluid is not without challenges.

Method used

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  • Methods For Detection Of Gastric Cancer
  • Methods For Detection Of Gastric Cancer
  • Methods For Detection Of Gastric Cancer

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Embodiment Construction

[0025]A mouse xenograft model is an alternative to analysis of clinical samples for biomarker discovery. It presents less genetic and biological variations compared to a human model at the same time allowing environmental factor to be tightly controlled (Frese, K K.; Tuveson, D. A., Nat Rev Cancer 2007, 7, (9), 645-58). Another advantage is that the xenograft model tends to have bigger tumor / blood ratio than humans, thereby enabling easier detection of cancer-induced changes. The feasibility of using a xenograft model for biomarker discovery had been demonstrated by various serum biomarker studies including that for breast (Pitteri, S. et al., J Proteome Res 2008, 7, (4), 1481-9), pancreas (Faca, V. M. et al., PLoS Med 2008, 5, (6), e123), stomach (Juan, H. F. et al., Proteomics 2004, 4, (9), 2766-75) and prostate (van Weerden, W. M.; Romijn, J. C., Prostate 2000, 43, (4), 263-71). For example, identification of nm23 / nucleoside-diphosphate kinase and human glycolytic enzyme in prost...

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Abstract

The invention is directed to non-invasive methods of detecting gastric cancer in an individual in need thereof comprising determining an expression level of inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) in the individual and comparing the expression level to a control, wherein an increase in the expression level of ITIH3 in the individual compared to the control is indicative of gastric cancer in the individual.

Description

RELATED APPLICATION(S)[0001]This application claims the benefit of U.S. Provisional Application No. 61 / 397,299, filed on Jun. 10, 2010. The entire teachings of the above application are incorporated herein by reference.BACKGROUND OF THE INVENTION[0002]Gastric cancer is the second leading cause of cancer-related deaths worldwide and early detection is the key in its management. Endoscopy is widely used for screening; however this methodology involves invasive procedure and its cost effectiveness remains an issue. One of the main goals in molecular biomarker discovery today is to develop a non / minimally-invasive method for cancer screening. In clinical diagnosis, body fluids especially plasma, serum and urine are frequently sampled from patients since they are easily obtained without complicated procedures. Hence, they represent ideal substrates for diagnostic purposes. However biomarker discovery in body fluid is not without challenges. The wide dynamic range of more than 9 orders of...

Claims

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Application Information

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IPC IPC(8): G01N33/566G01N33/577
CPCG01N33/57446G01N2333/811G01N2800/54G01N2800/52G01N2800/50
Inventor LIM, YOON PINCHONG, SHIRLY POH KUAN
Owner NAT UNIV OF SINGAPORE
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