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a technology of formulations and antifungals, applied in the field oftopical formulations, can solve the problems of undesirable side effects, no topical dermatologic preparation that is suitable for almost all skin types, and inability to use fluorinated and/or potent steroids for topical treatment for extended periods of time, and achieve the effect of sacrificing efficacy
Inactive Publication Date: 2012-06-28
GOLDSTEIN JAY A +2
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Problems solved by technology
Currently, there is no topical dermatologic preparation that is appropriate for almost all of the skin conditions that are normally seen by pediatricians, internists, and dermatologists.
The disadvantage of such combinations is that it is undesirable to use fluorinated and / or potent steroids for topical treatment for extended periods of time.
Steroids can penetrate the skin and cause undesirable side effects, including skin atrophy, hypopigmentation, suppression of the hypothalamic-pituitary-adrenal axis, Cushing's syndrome, and appearance of telangectasias.
The remaining two products have only 1% hydrocortisone, which is too low in potency to have significant anti-inflammatory properties.
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I. Antifungal Formulation
[0011]Antifungal compositions for treating fungal infections or mycological illnesses include one or more antifungal agents as well as one or more anti-inflammatory agents. The composition also contains excipients and a pharmaceutical carrier. The useful steroid agents cause reduced side effects such as skin atrophy, perianal ulcers, striae, and skin pigmentary changes.
[0012]A. Antifungal Agents
[0013]A large number of antifungal agents are known in the art. Generally, these can be generally classified into two broad categories, polyene type antifungal agents and azole type antifungal agents. Exemplary polyene type antifungal agents are, for example, Amphoterican B, Nystatin, Flucytosin, and Natamycin. Exemplary azole type antifungal agents include, for example, Ketoconazole, Econoazole, Miconazole, Itraconazole, Fluconazole, Clotrimazole, Griseofulvin, Oxiconazole, Terconazole, Tioconazole, Clotrimazole, and Silver Sulfadiazine. Other representative antifung...
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Abstract
A topical composition and the method using the composition, which contains an antifungal agent and a low potency anti-inflammatory steroid which is safe and effective such as desonide or its derivative. The low potency steroid agent does not cause side effects such as skin atrophy, striae and hypopigmentation. The composition can be formulated in a dosage form such as a cream, ointment, gel, lotion, foam, powder, aerosol, spray, shampoo, or liquid solution. The composition can be used to treat a fungal disease such as tinea pedis, tinea capitis, tinea corporis, tinea versicolor, tinea cruris, and candidiasis as well as intertriginous dermatitis complicated by candidiasis.
Description
[0001]This application claims priority to U.S. Ser. No. 60 / 421,190, entitled “Antifungal Formulations” filed in the U.S. Patent and Trademark Office on Oct. 24, 2002, by Jay A. Goldstein, Michael Rothman and Whe-Yong Lo.BACKGROUND OF THE INVENTION[0002]The present invention relates to topical formulations useful for treating fungal diseases, canidiasis, intertriginous dermatitis and their related inflammation. In particular, the present invention relates to stable topical formulations containing an antifungal agent and an anti-inflammatory steroid.[0003]Currently, there is no topical dermatologic preparation that is appropriate for almost all of the skin conditions that are normally seen by pediatricians, internists, and dermatologists. Various formulations based on combinations of anti-fungals and steroids are described in U.S. Pat. Nos. 4,912,124, 5,002,938, 5,021,458, 5,110,809, 5,174,475, 5,219,877, 5,407,663, 5,310,545, 6,075,056, and 6,080,744. The disadvantage of such combina...
Claims
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Patent Type & Authority Applications(United States)
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