Antifungal formulations

Abstract

A topical composition and the method using the composition, which contains an antifungal agent and a low potency anti-inflammatory steroid which is safe and effective such as desonide or its derivative. The low potency steroid agent does not cause side effects such as skin atrophy, striae and hypopigmentation. The composition can be formulated in a dosage form such as a cream, ointment, gel, lotion, foam, powder, aerosol, spray, shampoo, or liquid solution. The composition can be used to treat a fungal disease such as tinea pedis, tinea capitis, tinea corporis, tinea versicolor, tinea cruris, and candidiasis as well as intertriginous dermatitis complicated by candidiasis.

Description

[0001]This application claims priority to U.S. Ser. No. 60 / 421,190, entitled “Antifungal Formulations” filed in the U.S. Patent and Trademark Office on Oct. 24, 2002, by Jay A. Goldstein, Michael Rothman and Whe-Yong Lo.BACKGROUND OF THE INVENTION[0002]The present invention relates to topical formulations useful for treating fungal diseases, canidiasis, intertriginous dermatitis and their related inflammation. In particular, the present invention relates to stable topical formulations containing an antifungal agent and an anti-inflammatory steroid.[0003]Currently, there is no topical dermatologic preparation that is appropriate for almost all of the skin conditions that are normally seen by pediatricians, internists, and dermatologists. Various formulations based on combinations of anti-fungals and steroids are described in U.S. Pat. Nos. 4,912,124, 5,002,938, 5,021,458, 5,110,809, 5,174,475, 5,219,877, 5,407,663, 5,310,545, 6,075,056, and 6,080,744. The disadvantage of such combina...

AI Technical Summary

Benefits of technology

"The patent describes a topical composition that combines a low potency anti-inflammatory steroid with an antifungal agent. The steroid minimizes side effects such as skin atrophy and striae. The composition can be applied in various forms such as a cream, ointment, gel, lotion, foam, powder, aerosol, spray, shampoo, or liquid solution. It has a slightly acidic pH and may contain solvents, emollients, humectants, preservatives, and other additives to adjust its properties. The composition is effective in treating fungal diseases with inflammation, such as tinea pedis, tinea corporis, tinea versicolor, and tinea cruris, as well as yeast diseases like candididasis and itertriginous dermatitis. The recommended daily application is twice a day to the affected areas. The combination of desonide and clotrimazole is preferred. Other non-halogenated or low to medium potency corticosteroids and antifungals can also be used."

Problems solved by technology

Currently, there is no topical dermatologic preparation that is appropriate for almost all of the skin conditions that are normally seen by pediatricians, internists, and dermatologists.

The disadvantage of such combinations is that it is undesirable to use fluorinated and / or potent steroids for topical treatment for extended periods of time.

Steroids can penetrate the skin and cause undesirable side effects, including skin atrophy, hypopigmentation, suppression of the hypothalamic-pituitary-adrenal axis, Cushing's syndrome, and appearance of telangectasias.

The remaining two products have only 1% hydrocortisone, which is too low in potency to have significant anti-inflammatory properties.

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