Compositions and methods for antimicrobial metal nanoparticles

a technology of metal nanoparticles and compositions, applied in the field of compositions and methods for antimicrobial metal nanoparticles, can solve the problems of bacteria's death, inability to explain antiviral effects, and depriving them of necessary activity, and achieve the effect of fast action and great efficacy

Inactive Publication Date: 2012-11-29
UHLMANN DONALD R +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]The inventors associated with this patent have made the surprising discovery that particles of certain copper salts have much greater efficacy against a broad range of microbes, viruses, molds and fungi than similar silver-based antimicrobial pa

Problems solved by technology

One of these is the “oligodynamic effect,” which qualitatively explains the effect on some microorganisms, but cannot explain antiviral effects.
When the Ag+ ion forms a complex with these biomolecules, they are rendered inactive, depriving them of necessary activity and eventually leading to the bacteria's death.
Silver ions can also complex with bacterial DNA, impairing the ability of the microorganisms to reproduce.
The mechanism for copper ions, on the other hand, is n

Method used

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  • Compositions and methods for antimicrobial metal nanoparticles
  • Compositions and methods for antimicrobial metal nanoparticles
  • Compositions and methods for antimicrobial metal nanoparticles

Examples

Experimental program
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Effect test

example 1

Synthesis and Functionalization of Ago Particles with Thiomalic Acid at Ag / SH=1 / 0.25 and Ag / Aspartic=1 / 5

[0173]1 g Solution A (0.371 mmol) was diluted with 2.39 g water. 2.47 g of Solution C (1.855 mmol) and 3-5 mins later 0.139 g Solution E (0.0926 mmol) were dropped under stirring into the diluted solution. After stirring further for 5 mins, 2 g Solution B (0.37 mmol) were dropped slowly into it under stirring. The final concentration of silver based on the calculation of metallic silver is 0.5% w / w.

example 2a

Synthesis and Functionalization of Ago Particles with Thioglycine at Ag / SH=1 / 0.25 and Ag / Aspartic=1 / 5

[0174]1 g Solution A (0.371 mmol) was diluted with 2.368 g water. 2.47 g Solution C (1.855 mmol) and 3-5 mins later 0.151 g Solution D (0.0925 mmol) were dropped under stirring into the diluted solution. After stirring further for 5 mins, 2 g Solution B (0.37 mmol) were dropped slowly into it under stirring. The final concentration of silver based on the calculation of metallic silver is 0.5% w / w.

example 2b

Synthesis and Functionalization of Ago Particles with Thioglycine at Ag / SH=1 / 0.25 and Ag / Aspartic=1 / 2

[0175]1 g Solution A (0.371 mmol) was diluted with 2.368 g water. 0.99 g Solution C and 3-5 mins later 0.151 g Solution D (0.0925 mmol) were dropped under stirring into the diluted solution. After stirring further for 5 mins, 2 g Solution B (0.37 mmol) were dropped slowly into it under stirring. The final concentration of silver based on the calculation of metallic silver is 0.5% w / w.

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Abstract

Embodiments of the invention are directed to a composition having antimicrobial activity comprising particles comprising at least one inorganic copper salt; and at least one functionalizing agent in contact with the particles, the functionalizing agent stabilizing the particle in a carrier such that an antimicrobially effective amount of ions are released into the environment of a microbe. The average size of the particles ranges from about 1000 nm to about 4 nm. Preferred copper salts include copper iodide, copper bromide and copper chloride. Preferred functionalizing agents include amino acids, thiols, hydrophilic polymers emulsions of hydrophobic polymers and surfactants.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Patent Application Ser. No. 61 / 519,523, filed May 24, 2011, and U.S. Provisional Patent Application Ser. No. 61 / 582,322 filed Dec. 31, 2011, both of which are incorporated herein by reference in their entirety.FIELD OF THE INVENTION[0002]The invention relates to antimicrobial compositions comprising inorganic copper salt nanoparticles, their preparation, combinations of copper-based nanoparticles with metal and other metal salt nanoparticles, application of the compositions to surfaces and methods of preparation and use.BACKGROUND OF THE INVENTION[0003]The antimicrobial effect of various metals and their salts has been known for centuries. Hippocrates wrote that silver had beneficial healing and antidisease properties, and the Phoenicians stored water, wine, and vinegar in silver bottles to prevent spoiling. In the early 20th century, silver coins were put in milk bottles to prolong the...

Claims

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Application Information

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IPC IPC(8): A01N59/20A01P1/00A01N25/04B82Y5/00
CPCA01N59/16A01N59/20A01N25/02A01N25/08A61P31/04A61P31/10A61P31/12
Inventor UHLMANN, DONALD R.AGRAWAL, ANOOPAKARSU, MURATCRONIN, JOHN P.
Owner UHLMANN DONALD R
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