System and stent for repairing endovascular defects and methods of use

Abstract

Disclosed are endovascular stents in which a portion of the stents have a bioactive coating for promoting repair of damaged vessels, systems comprising the stents, and methods of using the stents to promote occlusion of aneurysms and / or repair damaged vessels.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Application No. 61 / 544,104, filed Oct. 6, 2011, which is incorporated by reference in its entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]This invention was made with government support under Grant No. W81XWH-11-2-0067 awarded by the U.S. Department of Defense. The United States Government has certain rights in this invention.FIELD OF THE INVENTION[0003]The invention relates generally to a system, vascular stents and methods of repairing endovascular defects. More particularly, the present invention relates to a system, vascular stents, and methods for treating injured or defective blood vessels, including aneurysms, such as neurovascular aneurysms. The vascular stent employed in the system and methods of the invention includes a bioactive coating for use in treatment of injured or defective blood vessels, including intracranial or cerebral aneurysms.BACKGR...

AI Technical Summary

Benefits of technology

[0008]In one embodiment, the present invention includes an endovascular stent for use in repairing an injured, damaged, or defective blood vessel. The stent has the advantage of being suitable for occluding aneurysms and / or repairing damaged vessels.

[0011]In certain embodiments, the stent includes an underlayer between the stent surface and the magnetic layer in order to promote better adhesion of top layers.

Problems solved by technology

Intracranial or cerebral aneurysms, which occur in approximately 2% of the population, are frequently life-threatening when rupture occurs.

Although endovascular coiling has been effective in the treatment of narrow neck aneurysms, it is less effective in treating wide neck aneurysms.

The irregular interface between the coil mass and the parent artery increases the risk of thrombosis leading to stroke, especially in wide neck aneurysms.

Further, because filling the aneurysm sac with coils does not address the diseased parent artery segment, there remains a high risk of regional recurrence of an aneurysm.

However, stent-assisted coiling in the treatment of wide neck aneurysms is problematic due to challenges associated with the anatomical reconstruction of a large segmental parent artery defect and impaired durability of the affected vessel.

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