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Composition for preventing or improving peripheral neuropathy

a peripheral neuropathy and composition technology, applied in the field of compositions for preventing or improving peripheral neuropathy, can solve the problems of deformation and rupture of knee cartilage and meniscus, decreased knee joint function, over-retention of synovial fluid, etc., to prevent or improve activity decline, improve peripheral neuropathy, and relieve peripheral neuropathic pain.

Inactive Publication Date: 2017-02-09
AJINOMOTO CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a new composition that can help prevent or improve peripheral neuropathy. This composition can help relieve pain caused by peripheral neuropathy and is safe to ingest over a long period of time. The composition contains serine and n-3 fatty acid, which are well-established ingredients with safety profiles. The QOL of the individual who consumes this composition is improved.

Problems solved by technology

Loss of muscle strength, aging, obesity, and the like in elderly people triggers a decrease in the function of knee joint, which in turn induces loose engagement, deformation and rupture of knee cartilage and meniscus.
In many of these cases, over-retention of synovial fluid occur due to inflammation and causes pain.
It induces looseness, deformation or rupture of engagement in the waist part, which often accompanies chronic pain.
Particularly, pain caused by chemotherapy often forces the chemotherapy to be stopped, and pain in the chemotherapy forms a large obstacle to the cancer treatment (see Folia Pharmacol. Jpn., 136, p275-279 (2010) which is incorporated herein by reference in its entirety).
Peripheral neuropathic pain is being treated systematically with opioid central analgesics such as morphine and the like; steroid; non-steroidal antiphlogistic analgesic; vitamin and the like; however, the side effects are strong and a sufficient effect is not obtained (see Neurological Therapeutics, vol.
However, all of these reports are in vitro evaluations in the initial process of nerve cell development, and the situation is vastly different from that of peripheral neuropathy after formation of nerve cell.
On the other hand, while eicosapentaenoic acid among n-3 fatty acids is already in clinical use as a hypertriglyceridemia improving agent, there is no clear clinical report relating to pain relief.

Method used

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  • Composition for preventing or improving peripheral neuropathy
  • Composition for preventing or improving peripheral neuropathy
  • Composition for preventing or improving peripheral neuropathy

Examples

Experimental program
Comparison scheme
Effect test

example 1

Granular Powder Nutrition Composition 1

[0119]Respective components shown in Table 2 were nixed in a compact high-speed mixer (NSK-150S, manufactured by OKADA SEIKO CO., LTD.) for 5 minutes. Thereafter, to the mixture were added distilled water and 99.5% alcohol at 2 to 5 wt %, and the mixture was kneaded in the mixer for 5 minutes to give a moistened kneaded mixture. The moistened kneaded mixture was granulated by an extrusion granulator with a 1.0 mmφ screen, and the obtained formed product was dried at normal pressure, 70° C. for 2 hours and sieved and 1.05 g of the granule was filled in an aluminum bag. The thus-obtained granular powder nutrition composition 1 was preserved at 24° C. for one year. All components were stably present even after the preservation. The granular powder nutrition composition 1 could be used by mixing with a nutritional supplement dissolved in warm water, and could also be Formulated as ion drinks. Furthermore, the composition was mixed with spice, salts...

example 2

Granular Powder Nutrition Composition 2

[0120]In the same manner as in Example 1 except that kneading was performed by a mortar instead of the high-speed mixer, and a horizontal extruder (manufactured by limited company UMETANI iron factory) was used as the extrusion granulator, granular powder nutrition composition 2 was obtained.

example 3

Liquid Composition-Filled Capsule Product

[0121]Respective components shown in Table 3 were mixed and filled in a soft capsule made of a plant-derived coating film to the total weight of 343.747 mg, and packed in an aluminum bag. The thus-obtained liquid compositions (Examples 2-1, 2-2) were preserved under 24° C., humidity 78% conditions for one year. All components were stably present even after the preservation.

TABLE 3mixing ratio (wt %)Example 2-1Example 2-2L-serine45.511.0fish oil (containing 28 wt % EPA,45.580.0containing 40 wt % n-3 fatty acid)plant-derived fats and oils2.12.1Beeswax6.76.7plant lecithin0.20.2total amount100100

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Abstract

Compositions which contain an amino acid containing serine and a lipid containing a n-3 fatty acid are useful for the prophylaxis or improvement of peripheral neuropathy.

Description

CROSS REFERENCES TO RELATED APPLICATIONS[0001]This application is a continuation of International Patent Application No. PCT / JP2015 / 062092, filed on Apr. 21, 2015, and claims priority to Japanese Patent Application No. 2014-088051, filed on Apr. 22, 2014, both of which are incorporated herein by reference in their entireties.BACKGROUND OF THE INVENTION[0002]Field of the Invention[0003]The present invention relates to compositions which are useful for the prophylaxis or improvement of peripheral neuropathy. The present invention also relates to methods for the prophylaxis or improvement of peripheral neuropathy.[0004]Discussion of the Background[0005]Pain is classified into “neuropathic”, “nociceptive”, and “psychogenic” pain, and these three types of pain act independently or compositely to cause a pain. “Neuropathic” pain easily becomes chronic, and shows different characteristics from “nociceptive” pain including many acute pains (e.g., injury, burn, etc.). Acute pain, which follo...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/202A61K35/60A61K31/198
CPCA61K31/202A61K35/60A61K31/198A61P25/02A61P25/04A61P43/00
Inventor MINE, TOMOYUKIUCHIDA, RYOHAYASHI, NAOKI
Owner AJINOMOTO CO INC
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