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Measurement device

Inactive Publication Date: 2018-01-25
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is a measurement device that uses the SPR phenomenon to detect and quantify the amount of an object on a MOS sensor cell. The device is compact, portable, and easy to operate. It is sensitive and accurate, making it useful for even non-experts in a home environment.

Problems solved by technology

In other words, the measurement device disclosed in Patent Literature 1 is not suitable for simply measuring the amount of the mite allergen in an ordinary environment (for example, a hot and humid state filled with dust) as in a general house and is not assumed to be portable.
Further, in the measurement device disclosed in Patent Literature 1, in order to set a sample case (sensor chip), it is necessary to apply matching oil between a prism and the sample case, and hence an operation is significantly complicated.
In addition, the amount of the allergen extracted from house dust is extremely small, and the aqueous solution amount thereof is also small.
Therefore, in a prism-type measurement device using only one reflection, the sensitivity is liable to be insufficient, and hence high accuracy is required in the fixing amount of an anti-allergen antibody, and a light source and a light receiving element.
However, the above-mentioned problems are not limited to the quantification of the amount of the mite allergen and are common to a measurement device configured to measure and / or quantify the amount of an object to be inspected through use of the SPR phenomenon.

Method used

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Examples

Experimental program
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example 1

[0087]In this Example, the effect of providing a reference unit and a development unit was verified.

[0088]First, the SPR sensor cell as illustrated in FIG. 3 to FIG. 5 was manufactured by a method in accordance with a method described in Example 1 of JP 2012-215540 A. An optical waveguide (substantially, a core layer) was branched into two optical waveguides. An antibody against Derf I was carried onto a metal layer on one of the core layers to form a detection unit, and a metal layer on the other core layer was used as it is as a reference unit. Further, a development unit (membrane filter made of hydrophilic polytetrafluoroethylene (PTFE) (Omnipore, JAWP09025, manufactured by Merck Ltd.) having a pore diameter of 1.0 μm, a thickness of 85 μm, a porosity of 80%, and a protein adsorption ratio of 4 μg / cm2) was arranged on the optical waveguides (substantially, across the two metal layers). The SPR sensor cell was inserted to be mounted on the cell mounting portion of the measurement...

example 2

[0091]An SPR sensor cell was manufactured in the same manner as in Example 1 except that the development unit was not provided. FIG. 12 is a graph for showing the comparison of a transmittance change between the detection unit and the reference unit, and FIG. 13 is a graph for showing the difference in transmittance change between the detection unit and the reference unit. As shown in FIG. 12 and FIG. 13, a change ratio in the detection unit was larger than that in the reference unit after an elapse of about two minutes from dropping of the sample liquid and was able to be measured and quantified with allowable sensitivity and accuracy. However, as shown in FIG. 12 and FIG. 13, a transmittance in only the reference unit changed within about one minute from dropping of the sample liquid, and hence a reverse phenomenon occurred in the difference in transmittance change between the detection unit and the reference unit within this time range. It is understood from the foregoing that, t...

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Abstract

The present invention provides a measurement device which is compact and portable and is simply operated, and which is capable of quantifying the amount of an object to be inspected with high sensitivity and high accuracy. A measurement device of the present invention includes an SPR sensor cell, a light source, and a light receiving element. The SPR sensor cell includes a plurality of optical waveguides. At least one of the plurality of optical waveguides forms a detection unit together with a metal layer onto which a recognition substance for an object to be inspected is fixed, and at least another one of the plurality of optical waveguides forms a reference unit together with a metal layer free of the recognition substance.

Description

TECHNICAL FIELD[0001]The present invention relates to a measurement device, and more specifically, to a measurement device configured to measure an amount of an object to be inspected through use of surface plasmon resonance and an optical waveguide.BACKGROUND ART[0002]A measurement device configured to measure the amount of an object to be inspected through use of a surface plasmon resonance (SPR) phenomenon has been known. Such a measurement device can be used for various chemical analyses and biochemical analyses; for example, measurement of the concentration of a sample and detection of an immune reaction. Examples of the application of those chemical analyses and biochemical analyses include detection of an allergen and / or quantification of the amount of the allergen. In particular, a main allergen in allergy diseases such as infant asthma and atopic dermatitis is considered to be derived from mites contained in indoor dust (house dust). Therefore, it is significantly important...

Claims

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Application Information

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IPC IPC(8): G01N21/552G01N33/573G01N33/543
CPCG01N21/554G01N33/54373C12Y304/22065G01N33/573G01N2333/96413G01N21/41
Inventor IHARA, TERUKAZUNISHIO, HAJIMEHATAKEYAMA, YOSHIHARUYANO, CHIHARUNA KANO, JUNKO
Owner NITTO DENKO CORP
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