Skin care applications of extracellular metabolites from bacillus coagulans
a technology of bacillus coagulans and extracellular metabolites, which is applied in the field of skin care applications of extracellular metabolites isolated from bacillus coagulans, can solve the problems of increasing oxidative stress and inflammation in the skin, affecting the appearance of skin,
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n Against UV Radiation
[0024]Isolation of Extracellular Metabolite
[0025]The extracellular metabolite from Bacillus coagulans MTCC 5856 was isolated as per the steps outlined in U.S. Pat. No. 9,596,861. The product is commercially available under the tradename LACTOSPORIN® (INCI: Bacillus ferment filtrate extract) from Sabinsa Corporation, USA.
[0026]Materials and Methods
[0027]The amount of UVA radiation on earth's surface is approximately 20-fold higher than that of UVB. It is responsible for the tanning effects of human skin and had been considered mostly harmless for many years. UV radiation has broad spectrum, ranging from 40 to 400 nm (30-3 eV), which is divided into Vacuum UV (40-190 nm), Far UV (190-220 nm), UVC (220-290 nm), UVB (290-320), and UVA (320-400 nm), of which the latter two are medically important. There are two distinct subtypes of UVA radiation. Short-wave UVA (320-340 nm) and long-wave UVA (340-400 nm), constitute most of UVA radiation. The amount of exposure to U...
example 2
n Against UV Induced DNA Damage
[0038]Isolation of Extracellular Metabolite
[0039]The extracellular metabolite from Bacillus coagulans MTCC 5856 was isolated as per the steps outlined in U.S. Pat. No. 9,596,861. The product is commercially available under the tradename LACTOSPORIN® (INCI: Bacillus ferment filtrate extract) from Sabinsa Corporation, USA.
[0040]Materials and Methods
[0041]UV light can accelerate premature ageing and DNA damage. UVB-induced apoptosis is the programmed cell death of cells that become damaged by ultraviolet rays. Apoptosis is a physiological process that promotes cell death which can be termed as active suicide of cells. Failure of the body to remove DNA damaged cells increases the risk of skin cancer. Reduction in apoptosis and cell death is hallmark of anti ageing molecule.
[0042]Materials
[0043]Cells: Skin cells (dermal fibroblasts, keratinocytes or melanocytes) purchased from American Type Culture Collection (ATCC, Manassas, Va.) and maintained as a monola...
example 3
in Oxidative Stress Induced by UV Radiation
[0051]Isolation of Extracellular Metabolite
[0052]The extracellular metabolite from Bacillus coagulans MTCC 5856 was isolated as per the steps outlined in U.S. Pat. No. 9,596,861. The product is commercially available under the tradename LACTOSPORIN® (INCI: Bacillus ferment filtrate extract) from Sabinsa Corporation, USA.
[0053]Materials and Methods
[0054]Skin cells are constantly exposed to reactive oxygen species (ROS) and oxidative stress from exogenous and endogenous sources. UV radiation is the most important environmental factor in the development of skin cancer and skin aging. Oxidative stress is developed in skin when the UV-induced generation of ROS exceeds the ability of endogenous defence mechanism. The reduction of oxidative stress can be achieved either by lowering exposure to UVR and / or by increasing levels of antioxidant defence mechanism. Melanin present in the skin and the anti oxidant enzymatic reactions protect our skin from...
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