Skin care applications of extracellular metabolites from bacillus coagulans

a technology of bacillus coagulans and extracellular metabolites, which is applied in the field of skin care applications of extracellular metabolites isolated from bacillus coagulans, can solve the problems of increasing oxidative stress and inflammation in the skin, affecting the appearance of skin,

Inactive Publication Date: 2018-12-06
SAMI LABS LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The human skin is exposed to a wide range of environmental pollutants and harmful UV radiation, damaging the skin and leading to premature aging, Exposure to these harmful pollutants and UV radiation will increase the production of reactive oxygen species (ROS) and inflammatory markers, increasing the oxidative stress and inflammation in the skin cells thereby damaging the cellular biomolecules (lipids, sugars, proteins, and polynucleotides).
However, it is well known in the scientific art that biological effects of probiotics or products thereof are strain specific and cannot be generalised among genera, species and strains (Probiotics: Depth / NCCIH, U.S. Department of Health and Human Services, National Institutes of Health).

Method used

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  • Skin care applications of extracellular metabolites from bacillus coagulans
  • Skin care applications of extracellular metabolites from bacillus coagulans
  • Skin care applications of extracellular metabolites from bacillus coagulans

Examples

Experimental program
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Effect test

example 1

n Against UV Radiation

[0024]Isolation of Extracellular Metabolite

[0025]The extracellular metabolite from Bacillus coagulans MTCC 5856 was isolated as per the steps outlined in U.S. Pat. No. 9,596,861. The product is commercially available under the tradename LACTOSPORIN® (INCI: Bacillus ferment filtrate extract) from Sabinsa Corporation, USA.

[0026]Materials and Methods

[0027]The amount of UVA radiation on earth's surface is approximately 20-fold higher than that of UVB. It is responsible for the tanning effects of human skin and had been considered mostly harmless for many years. UV radiation has broad spectrum, ranging from 40 to 400 nm (30-3 eV), which is divided into Vacuum UV (40-190 nm), Far UV (190-220 nm), UVC (220-290 nm), UVB (290-320), and UVA (320-400 nm), of which the latter two are medically important. There are two distinct subtypes of UVA radiation. Short-wave UVA (320-340 nm) and long-wave UVA (340-400 nm), constitute most of UVA radiation. The amount of exposure to U...

example 2

n Against UV Induced DNA Damage

[0038]Isolation of Extracellular Metabolite

[0039]The extracellular metabolite from Bacillus coagulans MTCC 5856 was isolated as per the steps outlined in U.S. Pat. No. 9,596,861. The product is commercially available under the tradename LACTOSPORIN® (INCI: Bacillus ferment filtrate extract) from Sabinsa Corporation, USA.

[0040]Materials and Methods

[0041]UV light can accelerate premature ageing and DNA damage. UVB-induced apoptosis is the programmed cell death of cells that become damaged by ultraviolet rays. Apoptosis is a physiological process that promotes cell death which can be termed as active suicide of cells. Failure of the body to remove DNA damaged cells increases the risk of skin cancer. Reduction in apoptosis and cell death is hallmark of anti ageing molecule.

[0042]Materials

[0043]Cells: Skin cells (dermal fibroblasts, keratinocytes or melanocytes) purchased from American Type Culture Collection (ATCC, Manassas, Va.) and maintained as a monola...

example 3

in Oxidative Stress Induced by UV Radiation

[0051]Isolation of Extracellular Metabolite

[0052]The extracellular metabolite from Bacillus coagulans MTCC 5856 was isolated as per the steps outlined in U.S. Pat. No. 9,596,861. The product is commercially available under the tradename LACTOSPORIN® (INCI: Bacillus ferment filtrate extract) from Sabinsa Corporation, USA.

[0053]Materials and Methods

[0054]Skin cells are constantly exposed to reactive oxygen species (ROS) and oxidative stress from exogenous and endogenous sources. UV radiation is the most important environmental factor in the development of skin cancer and skin aging. Oxidative stress is developed in skin when the UV-induced generation of ROS exceeds the ability of endogenous defence mechanism. The reduction of oxidative stress can be achieved either by lowering exposure to UVR and / or by increasing levels of antioxidant defence mechanism. Melanin present in the skin and the anti oxidant enzymatic reactions protect our skin from...

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Abstract

Disclosed are the skin care applications of a composition containing the partially purified extracellular metabolite isolated from Bacillus coagulans MTCC 5856. More specifically, the invention discloses the ability of the partially purified extracellular metabolite isolated from Bacillus coagulans MTCC 5856 to confer protection to the skin fibroblasts against UV induced cell damage and apoptosis, oxidative stress and inflammation.

Description

CROSS-REFERENCE TO RELATED PATENT APPLICATIONS[0001]The present invention is non-provisional filing of U.S. provisional patent application No. 62 / 516,090 filed on 6 Jun. 2017 and 62 / 523,620 filed on 22 Jun. 2017.BACKGROUND OF THE INVENTIONField of the Invention[0002]The invention in general relates to probiotics. More specifically, the present invention discloses the skin care applications of extracellular metabolite isolated from Bacillus coagulans MTCC 5856.Description of Prior Art[0003]The human skin is exposed to a wide range of environmental pollutants and harmful UV radiation, damaging the skin and leading to premature aging, Exposure to these harmful pollutants and UV radiation will increase the production of reactive oxygen species (ROS) and inflammatory markers, increasing the oxidative stress and inflammation in the skin cells thereby damaging the cellular biomolecules (lipids, sugars, proteins, and polynucleotides). Protection against these agents will eventually improve ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/99A61Q17/04
CPCA61K8/99A61Q17/04A61Q19/00A61Q19/08A61K2800/522A61P17/00
Inventor MAJEED, MUHAMMEDNAGABHUSHANAM, KALYANAMARUMUGAM, SIVAKUMARALI, FURQANMAJEED, SHAHEENMUNDKUR, LAKSHMI
Owner SAMI LABS LTD
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