Method for manufacturing nanoparticle array, surface plasmon resonance-based sensor and method for analyzing using same

Abstract

The present invention relates to a method for manufacturing a nanoparticle array, a surface plasmon resonance-based sensor, and a method for analyzing using the same. According to one embodiment of the present invention, after a mixed solution of an ionized binder and conductive nanoparticles is prepared, a substrate is dipped into the mixed solution. Thereafter, by applying an electric field to the mixed solution into which the substrate is dipped so as to induce coating of the conductive nanoparticles on the substrate, it is possible to manufacture, by a wet method, a nanoparticle array in which the conductive nanoparticles are quickly coated on the substrate with high density.

Description

INCORPORATION BY REFERENCE OF ANY PRIORITY APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 14 / 784,569, filed on Feb. 4, 2016, which is a national stage application under 35 U.S.C. § 371 of PCT Application No. PCT / KR2013 / 008182, filed on Sep. 10, 2013, which claims priority to Korean Patent Application No. 10-2013-0041228, filed on Apr. 15, 2013, and to Korean Patent Application No. 10-2013-0083142, filed on Jul. 15, 2013. Each of the above applications is incorporated herein by reference in its entirety.TECHNOLOGICAL FIELD[0002]The present invention describes a sensor technology for detecting biological or non-biological substances. In more detail, a method for manufacturing a nanoparticle array, a surface plasmon resonance-based sensor and a method for analyzing using the same.BACKGROUND TECHNOLOGY[0003]A surface plasmon resonance (SPR) refers to a phenomenon of the propagation of surface plasmon polaritons (SPPs) which are formed on or near...

AI Technical Summary

Benefits of technology

[0012]Referring to the present invention, a cost-effective wet method to manufacture a nanoparticle array can be offered through quick and high density coating of metal nanoparticles onto the substrate by dipping the substrate into a mixed solution of an ionic binder and conductive nanoparticles followed by applying an electric filed outside.

[0013]In addition, referring to the present invention, a sensor with an enhanced detection sensitivity, which depends on a kind and concentration of a target analyte, can be offered by adapting the high metal nanoparticle density sensor for a SPR or LSPR mode-based spectroscopic analysis. In addition, in the case of performing a SPR or LSPR-based spectroscopic analysis after multiple stacking of the stated sensor, it can be easy to amplify a measurement sensitivity practically as much as the number of stacked sensor through the effect of an increased conductive metal nanoparticle density per unit light transmitted area.

Problems solved by technology

However, such conventional technologies have limitations in improving production yield upon applying continuous processes or various substrate sizes.

Furthermore, the conventional technologies often lead to defective products due to defects or contaminations, in the case of requiring a mechanical contact.

In this case, however, substrate materials for nano-island formation are limited to heat-resisting materials such as glass and there is a problem of not obtaining a nanoparticle array with a high nanoparticle density.

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