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Phenotype measurement systems and methods

a phenotype and measurement system technology, applied in the field of detection and analysis of phenotypes, can solve the problems of unsupervised machine learning in the construction of classification profiles, and achieve the effects of simplifying data storage, high throughput, and short time period

Inactive Publication Date: 2019-12-19
FENOLOGICA BIOSCI INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a system that can quickly and automatically analyze two-dimensional or three-dimensional cell or colony cultures from various samples. The system can handle a large number of samples simultaneously and can automate image acquisition, data processing, and analysis. It can also identify different phenotypes based on colony growth, color, and structural morphology, and can be used with different types of plates and media. Overall, the system reduces manual labor and time and can provide quick and accurate results.

Problems solved by technology

In some aspects, building the classification profile comprises unsupervised machine learning.

Method used

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  • Phenotype measurement systems and methods
  • Phenotype measurement systems and methods
  • Phenotype measurement systems and methods

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Embodiment Construction

[0024]The systems, methods, and devices described herein can be used to automatically and efficiently process experimental data from one or more experiment. In some embodiments, these systems, methods, and devices can be configured to coordinate and perform analysis and classification of massive data sets received from a plurality of data acquisition tools. For example, the systems, methods, and devices described herein can be used to automatically extract a customizable set of aspects or features from imaging data acquired from a plurality of high-throughput data acquisition tools, build an ontological classification profile based on features extracted from massive quantities of raw data, and apply the classification profile within or across data sets. Since a single instance of such analysis may use the functions or capabilities of a plurality of data acquisition tools (which can include one or more data processing system such as one or more computational tools), the systems, meth...

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Abstract

An image acquisition and analysis system is disclosed. The system enables high throughput, objective analysis of microbial samples over days or weeks. The system may accommodate upwards of twelve 96- or 384-well plates simultaneously (liquid or solid media). The system may acquire and analyze a large number of samples in a short period of time. For example, over 384 samples per minute or 18,432 samples per hour. The system hardware may include a multi-spectral imager (fluorescence and bright field detection), electro-mechanical assemblies, and an optional high-resolution stage. The system may automate image acquisition, image data processing, simplify data storage, and enable automated analysis tools to significantly reduce the manual labor and time associated with such tasks. The system may allow for quick processing and analysis of data into clear phenotypic classes. The analysis capabilities may include colony growth, colorimetry, and structural morphology assays, and automated phenotype classification capabilities.

Description

CROSS REFERENCE[0001]This application claims the benefit of U.S. Provisional Patent Application No. 62 / 467,011, filed Mar. 3, 2017, the entire disclosure of which is incorporated by reference.TECHNICAL FIELD[0002]This disclosure is generally related to the detection and analysis of phenotypes. More particularly, this disclosure is related to the automated detection, analysis, and classification of phenotypes of cellular assays.BACKGROUND OF THE INVENTION[0003]Current instrumentation for phenotype measurement is not keeping pace with the scale in which modern microbiology and cell molecular biology is performed. Quantitative methodologies are used to study cellular functions, the molecular mechanisms underlying specific phenotypes, and the levels of RNAs, proteins, and metabolites. For example, insights about the virulence or drug resistance of pathogenic bacteria or fungi could be gained from quantitative growth dynamics and morphological analyses of cellular colonies over extended ...

Claims

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Application Information

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IPC IPC(8): G16B40/30C12M1/36G16B45/00G16H10/40G06K9/00
CPCG16B40/30G16H10/40G01N2015/1006G16B45/00C12M41/48G16H30/40G06K9/00147G01N15/1429G01N15/1475G06K9/0014C12M41/36G01N15/0612G16H30/20G16H50/70Y02A90/10G06V20/69G01N15/1433G06V20/695G06V20/698
Inventor WRIGHT, MATTHEW IANSCOTT, ADRIAN CHRISTOPHERMACLEOD, SEAN MATTHEWKUHN, MEGAN LEW
Owner FENOLOGICA BIOSCI INC