Eye drops to treat chemically induced corneal damage
a technology of eye drops and chemical induced corneal damage, which is applied in the direction of pharmaceutical delivery mechanism, drug composition, organic active ingredient, etc., can solve the problems of corneal damage, pain, irreversible blindness, and no therapy currently exists to counter sm's toxicity to the eye, and achieve the effect of effectively reducing nm-toxicity to the cornea
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example 1
Acute MGK Pathology, Loss of Epithelial Barrier and Recurrent Corneal Epithelial Erosions, in Rabbits In Vivo by Topical TED
[0111]FIGS. 1A-1H show results of a clinical diagnostic Fluorescein eye test. This test is specific for reading loss of epithelial barrier and corneal erosions by gauging the area and density of green-dye uptake in the cornea, which tells extent of erosions and defects in corneal epithelium. SM contact to rabbit eyes showed dramatically increased epithelial erosion and deformations on day-3 (FIG. 1C) and day-7 (FIG. 1G) as pointed by the arrowheads compared to the naive (FIG. 1A, FIG. 1E) or TED-alone treated (FIG. 1B, FIG. 1F) eyes. Topical TED (twice daily for 5 days) on SM-exposed eyes prevented breach in epithelial barrier and erosions as no fluorescein uptake was noted on day-3 (FIG. 1D) or day-7 (FIG. 1H). Interestingly, 50% (3 out of 6) SM-exposed rabbit eyes showed recurring corneal epithelial erosion after 1-month (FIG. 2A) but none of SM+TED eyes at 1...
example 2
Other Acute MGK Symptoms
[0112]Remarkable mitigation of SM-induced epithelial-stromal disruption, basement membrane damage, and corneal edema was noted in human cornea ex vivo (FIG. 3A-3F) and rabbit eyes in vivo (FIG. 4A-4B) as shown by H&E and integrin-β4 immunostaining specific for the cornea. Rabbit eyes and human corneas in organ culture exposed to SM / NM were analyzed. In human cornea, ex vivo, vehicle (FIG. 3A, FIG. 3D) did not cause injury but nitrogen mustard (NM, 200 μM 30 s; SM-analog) exposure led to acute MGK (FIG. 3B, FIG. 3E). The NM+TED (twice daily for 5 days) treatments showed dramatic rescue of cornea from NM-injury (FIG. 3C, FIG. 3F). In rabbit eyes, in vivo, SM-exposed corneas showed hefty epithelial-stromal separation, basement membrane damage, and edema (FIG. 4A), and a remarkable mitigation of these pathologies was detected in SM+TED corneas (FIG. 4B). It is possible that LSCD and inflammatory cytokines play important role in producing these pathologies of acut...
example 3
n SM-Induced Acute MGK Pathology Involving Corneal Haze, Edema, and Tearing
[0113]Rabbit eyes were exposed to SM in + / −TED and live rabbits were examined with slit-lamp and stereo biomicroscopy, pachymetry, and Schirmer eye test in in a real-time manner. Clinical exams performed by 2 ophthalmologists and 1 cornea-scientist in a masked manner found no symptoms such as conjunctival hyperemia, uveitis, corneal opacity, recurrent epithelial defects, dry eye, or compromised intraocular pressure in naive (FIG. 5A, FIG. 5E, FIG. 5I) or TED-alone treated rabbit eyes (FIG. 5B, FIG. 5F, FIG. 5J) at day 3, day 7, or day 45. Conversely, SM-exposed rabbit eyes demonstrated a significantly high corneal haze and edema on day-3 (FIG. 5C), day-7 (FIG. 5G) and day-14 (FIG. 5K). Topical TED application on SM-vapor exposed eyes markedly reduced corneal haze (an acute MGK) on day-3 (FIG. 5D), on day-7 (FIG. 5H) and on day-14 (FIG. 5L) compared to corresponding-day SM-exposed rabbit eyes (FIG. 5C, FIG. 5G...
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