Method of re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide

US6953861B2Inactive Publication Date: 2005-10-11THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
Publication Date
2005-10-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to pyrrolidine compounds of the general structure: where n is an integer 1-6 and R is hydrogen or a C1 to C6 straight chain or branched alkyl group, and wherein when n=1, R=CH3 or H, useful for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond on the cell wall peptide precursors of the bacteria.
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Description

[0001] This application is a continuation of U.S. Ser. No. 09 / 938,746, filed Aug. 23, 2001, now U.S. Pat. No. 6,734,165 now allowed, the contents of which are hereby incorporated by reference into the present application.

[0002] The invention disclosed herein was made with Government support under NIH Grant No. 5-R01-HL-25634-18 from the National Institutes of Health. Accordingly, the U.S. Government has certain rights in this invention.

[0003] Throughout this application, various references are identified by citations or a number in parenthesis, in which case their full citations appear on the pages following the Detailed Description immediately preceding the claims. Disclosure of these references in their entireties are hereby incorporated by reference into this application to more fully describe the state of the art to which this invention pertains.FIELD OF THE INVENTION

[0004] The present invention relates to a method for re-sensitizing vancomycin resistant Gram-positive bacteria in wh...

Claims

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