Delivery system for heparin-binding growth factors

a technology of growth factor and delivery system, which is applied in the field of proteoglycans, can solve the problems of defective endochondral ossification, large amount of inventive proteoglycan production, and severe disorganization of the columnar structure of chondrocytes
US7671018B2Inactive Publication Date: 2010-03-02UNIVERSITY OF DELAWARE
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
UNIVERSITY OF DELAWARE
Publication Date
2010-03-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

New uses of proteoglycans to bind and present growth factors, methods of accelerating wound, tissue or bone repair using such proteoglycans, pharmaceutical compositions of such proteoglycans, and scaffolds coated with such proteoglycans are disclosed. The proteoglycan of the invention is derived from domain I or perlecan.
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Description

RELATED APPLICATIONS

[0001] This application is a national stage application (under 35 U.S.C. 371) of PCT / US01 / 26512 filed Aug. 27, 2001, which claims the benefit of U.S. Application No. 60 / 228,935 filed Aug. 30, 2000, which is hereby incorporated herein in its entirety.GOVERNMENT INTERESTS

[0002] This invention was made with Government support under Grant (or Contract) No. HD25235 awarded by the National Institutes of Health. The Government has certain rights in this invention.BACKGROUND OF THE INVENTION

[0003] The invention provides new uses and compositions of proteoglycans. The proteoglycans are derived from perlecan, an extracellular matrix protein. The inventive proteoglycans retain certain desirable activities of the full-length perlecan molecule, such as the ability to bind growth factors, yet they have a size that allows for effective preparation and application as is not the case for perlecan. Furthermore, large amounts of the inventive proteoglycan can be produced in mammalian ...

Claims

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