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Periodic contrast injections and analysis of harmonics for interventional X-ray perfusion imaging

a perfusion imaging and contrast injection technology, applied in the field of perfusion imaging apparatuses, can solve the problems of inability to meet the needs of c-arm type interventional imaging systems, tomographic dynamic perfusion imaging methods for slow rotating interventional imaging systems, where spatial resolution is substantially preserved, and achieve the effects of avoiding or eliminating signal aliasing, reducing temporal signal aliasing, and reducing signal aliasing

Inactive Publication Date: 2017-05-09
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes an apparatus for X-ray perfusion imaging that improves the workflow and accuracy of procedures using a slow rotating X-ray scanner. The apparatus uses a control unit to generate a control signal for an injector unit to deliver a contrast agent to an object in a periodic manner, instead of a single bolus injection. The injection rate is adjusted to mitigate temporal signal aliasing in the X-ray attenuation signal sample. The repeated injections have a discrete spectrum that can be distinguished from the continuous spectrum of a single bolus injection and is used to extract dynamic perfusion parameters such as blood flow and mean transit time. The apparatus can be used in interventional procedures and provides a safer and more efficient means of performing X-ray perfusion imaging.

Problems solved by technology

However, tomographic dynamic perfusion imaging methods for slowly rotating interventional imaging systems (for example of the C-arm type) where spatial resolution is substantially preserved are currently not available.

Method used

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  • Periodic contrast injections and analysis of harmonics for interventional X-ray perfusion imaging
  • Periodic contrast injections and analysis of harmonics for interventional X-ray perfusion imaging
  • Periodic contrast injections and analysis of harmonics for interventional X-ray perfusion imaging

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Embodiment Construction

[0036]With reference to FIG. 1, there is shown a perfusion imaging arrangement 100.

[0037]It includes an x-ray imager 105 of the C-arm type. X-ray imager 105 is used to acquire a sequence of x-ray projection images P of an organ of interest 111 to support an intervention.

[0038]In one embodiment, the organ of interest is a patient 108's heart or brain.

[0039]Patient 108 is placed on an examination table. Imager 105 comprises a rigid C-arm structure 106 journaled on a bearing. Journaling allows rotation of C-arm 140 around a at least one axis passing through journaling. C-arm structure 106 can thus be positioned at various rotation angles α around organ of interest 111.

[0040]C-arm 106 carries at one of its ends an x-ray source 107 and at the other end a detector 109 in opposed spatial relationship to said x-ray source 107. Detector 109 includes an array of detector cells (not shown).

[0041]During an imaging session, x-rays are emitted from x-ray source 107. X-rays pass through organ of i...

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Abstract

An apparatus (130) and a method for adjusting, in perfusion imaging system, a periodic contrast agent injection rate signal (IS) for an injector (135) as function of an image sampling rate determined by the rotational speed of an X-ray source (107)-detector (109) assembly of an X-ray imager (100). Frequency, periodicity and pulse width of the contrast agent injection rate signal (IS) is adjusted to mitigate temporal signal aliasing in a sample of a time attenuation contrast (TAC) signal.

Description

CROSS-REFERENCE TO PRIOR APPLICATIONS[0001]This application is the U.S. National Phase application under 35 U.S.C. §371 of International Application Serial No. PCT / IB2013 / 051568, filed on Feb. 27, 2013, which claims the benefit of U.S. Application Ser. No. 61 / 607,044 filed on Mar. 6, 2012. These applications are hereby incorporated by reference herein.FIELD OF THE INVENTION[0002]The present invention relates to an apparatus for supporting perfusion imaging, to a method for supporting perfusion imaging, to a medical x-ray for perfusion imaging, to a computer program element, and to a computer readable medium.BACKGROUND OF THE INVENTION[0003]Perfusion imaging may be used to gain clues on blood perfusion in soft tissue.[0004]Currently, perfusion imaging is used mainly for purely diagnostic purposes where the imaging is achieved by a fast rotating CT system mounted in a closed gantry. Tomographic reconstruction methods are repeatedly applied to projections acquired in a series of fast r...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61B5/05A61M5/32A61M5/172A61M5/315A61K49/04A61M5/00A61B6/03A61B6/00A61B6/02A61B34/00A61B90/00
CPCA61M5/007A61B6/025A61B6/032A61B6/4441A61B6/481A61B6/486A61B6/501A61B6/503A61B6/504A61B6/507A61B6/5217A61B6/542A61K49/04A61M5/172A61M5/315A61M5/32A61M2205/33G16H50/30
Inventor NEUKIRCHEN, CHRISTOPHRUIJTERS, DANIEL SIMON ANNA
Owner KONINKLJIJKE PHILIPS NV
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